Raszewski Grzegorz, Loroch Małgorzata, Owoc Alfred, Łukawski Krzysztof, Filip Rafał, Bojar Iwona
Department of Physiopathology, Institute of Rural Health, Jaczewskiego 2, 20-950, Lublin, Poland,
Arch Womens Ment Health. 2015 Aug;18(4):623-30. doi: 10.1007/s00737-015-0518-z. Epub 2015 Mar 31.
The purpose of the study was the analysis of cognitive functions in postmenopausal women having different status of homocysteine levels by a battery of computer tests-central nervous system vital signs (CNS-VS). We examined whether homocysteine increases the risk of cognitive decline and which cognitive domains are more affected. We showed that the considerably better neurocognitive index was obtained by women with low homocysteine levels in comparison with those with hyperhomocysteinemia (p = 0.0017). Similarly, results were obtained in the field of executive functioning (p = 0.0011), complex attention (p = 0.0106), cognitive flexibility (p = 0.0016), and memory (p = 0.0145). Verbal memory and visual memory did not differ considerably among the studied groups. Also, we demonstrated that ε4/ε4 genotype was the most common (15.5 %) in women with hyperhomocysteinemia than in groups of patients with low (0 %) or normal (1.9 %) homocysteine levels. In summary, hyperhomocysteinemia was related with increased risk of decline in executive functioning, complex attention, cognitive flexibility, and memory in postmenopausal women.
本研究的目的是通过一系列计算机测试——中枢神经系统生命体征（CNS-VS），分析不同同型半胱氨酸水平状态的绝经后女性的认知功能。我们研究了同型半胱氨酸是否会增加认知能力下降的风险以及哪些认知领域受影响更大。我们发现，同型半胱氨酸水平低的女性与高同型半胱氨酸血症女性相比，神经认知指数明显更好（p = 0.0017）。同样，在执行功能（p = 0.0011）、复杂注意力（p = 0.0106）、认知灵活性（p = 0.0016）和记忆（p = 0.0145）方面也得到了类似结果。在所研究的组中，言语记忆和视觉记忆没有显著差异。此外，我们还证明，与同型半胱氨酸水平低（0%）或正常（1.9%）的患者组相比，ε4/ε4基因型在高同型半胱氨酸血症女性中最为常见（15.5%）。总之，高同型半胱氨酸血症与绝经后女性执行功能、复杂注意力、认知灵活性和记忆下降风险增加有关。
