Bojar Iwona, Owoc Jakub, Wójcik-Fatla Angelina, Raszewski Grzegorz, Stančiak Jaroslav, Raczkiewicz Dorota
Department for Health Problems of Ageing, Institute of Rural Health, Lublin, Poland.
College of Public Health, Zielona Góra, Poland.
Ann Agric Environ Med. 2015;22(2):313-9. doi: 10.5604/12321966.1152086.
The objective of the study was investigation of the relationship between cognitive functions and lipid profile, BMI and change of body weight in postmenopausal women carriers of Apolipoprotein E gene polymorphisms (APOE). A group of 170 women was recruited to the study. The inclusion criteria were: minimum of two years after the last menstruation, FSH concentration 30 U/ml and no signs of dementia on the Montreal Cognitive Assessment (MoCA). A computerized battery of Central Nervous System Vital Signs (CNS VS) was used for diagnostic cognitive functions. APOE genotype was performed by multiplex PCR. In blood plasma were determined: triglycerides, total cholesterol and its fractions: HDL cholesterol and LDL cholesterol. Statistical analysis was performed using two-way analysis of variance in STATISTICA software. In the postmenopausal women examined, the carrier state of APOE gene polymorphism was associated with the level of triglycerides, and results concerning three cognitive functions: executive functions, psychomotor speed, and cognitive flexibility. Loss of body weight in postmenopausal women was related with lower results in neurocognitive index and the majority of cognitive functions. The results concerning cognitive functions in postmenopausal women in the study were not significantly related with lipid profile. Significant differences were observed according to APOE gene polymorphism in correlations between LDL/HDL and CHOL/HDL ratios, and results in the processing speed and reaction time, as well as between the BMI and results in processing speed in the postmenopausal women examined.
本研究的目的是调查载脂蛋白E基因多态性（APOE）的绝经后女性携带者的认知功能与血脂谱、体重指数和体重变化之间的关系。一组170名女性被纳入研究。纳入标准为：末次月经后至少两年，促卵泡激素浓度≥30 U/ml，且蒙特利尔认知评估（MoCA）无痴呆迹象。使用一套计算机化的中枢神经系统生命体征（CNS VS）来诊断认知功能。通过多重聚合酶链反应检测APOE基因型。测定血浆中的甘油三酯、总胆固醇及其组分：高密度脂蛋白胆固醇和低密度脂蛋白胆固醇。使用STATISTICA软件进行双向方差分析进行统计分析。在接受检查的绝经后女性中，APOE基因多态性的携带者状态与甘油三酯水平以及三项认知功能的结果相关：执行功能、精神运动速度和认知灵活性。绝经后女性体重减轻与神经认知指数及大多数认知功能的较低结果相关。本研究中绝经后女性的认知功能结果与血脂谱无显著相关性。在接受检查的绝经后女性中，根据APOE基因多态性观察到低密度脂蛋白/高密度脂蛋白和胆固醇/高密度脂蛋白比率与处理速度和反应时间结果之间的相关性存在显著差异，以及体重指数与处理速度结果之间存在显著差异。
