Mann Aniv, Semenenko Inessa, Meir Michal, Eyal Sara
Institute for Drug Research, School of Pharmacy, Faculty of Medicine, The Hebrew University, Room 613, Ein Kerem, Jerusalem, 91120, Israel.
AAPS J. 2015 Jul;17(4):788-801. doi: 10.1208/s12248-015-9752-6. Epub 2015 Mar 31.
Molecular imaging allows the non-invasive assessment of membrane transporter expression and function in living subjects. Such technologies have the potential to become diagnostic and prognostic tools, allowing detection, localization, and prediction of response of tumors and their metastases to therapy. Beyond tumors, imaging can also help understand the role of transporters in adverse drug effects and drug clearance. Here, we review molecular imaging technologies that monitor transporter-mediated processes. We emphasize emerging probe substrates and potential clinical applications of imaging the function of membrane transporters in cancer.
分子成像能够对活体受试者的膜转运蛋白表达及功能进行非侵入性评估。此类技术有潜力成为诊断和预后工具，可用于检测、定位肿瘤及其转移灶，并预测其对治疗的反应。除肿瘤外，成像还有助于了解转运蛋白在药物不良反应和药物清除中的作用。在此，我们综述监测转运蛋白介导过程的分子成像技术。我们着重介绍新兴的探针底物以及膜转运蛋白功能成像在癌症中的潜在临床应用。
