尤因肉瘤经骶骨切除联合化疗和放疗后成功妊娠：病例报告及文献综述
Successful Pregnancy After Sacrectomy Combined With Chemotherapy and Radiation for Ewing Sarcoma: Case Report and Literature Review.
作者信息
Kakogawa Jun, Nako Takafumi, Kawamura Kazuhiro, Nakamura Shin, Mochiduki Ayako, Kanayama Naohiro, Tanaka Mamoru
机构信息
Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kanagawa, Japan.
Department of Obstetrics and Gynecology, St. Marianna University School of Medicine, Kanagawa, Japan.
出版信息
J Pediatr Adolesc Gynecol. 2015 Jun;28(3):e79-81. doi: 10.1016/j.jpag.2014.06.009. Epub 2014 Jul 15.
BACKGROUND
Ewing sarcoma is considered to have a poor prognosis. Recent advances in multidisciplinary management have resulted in a marked improvement in long-term survival.
CASE
We describe a case of successful pregnancy in a patient who underwent sacrectomy combined with multi-agent chemotherapy and radiotherapy for Ewing sarcoma. The patient was diagnosed with Ewing sarcoma of the sacrum at the age of 16. The ovaries were transposed, the uterus was shielded, and a gonadotropin-releasing hormone agonist was used during treatment to protect ovarian function. The patient spontaneously conceived at the age of 27. After an uneventful pregnancy, the patient delivered a healthy neonate at term by cesarean section.
SUMMARY AND CONCLUSIONS
Successful pregnancy and delivery can be achieved after multi-modality treatment with pretreatment intervention for fertility preservation.
背景
尤因肉瘤被认为预后较差。多学科管理的最新进展已使长期生存率显著提高。
病例
我们描述了一例患者成功妊娠的病例，该患者因尤因肉瘤接受了骶骨切除术联合多药化疗及放疗。患者16岁时被诊断为骶骨尤因肉瘤。治疗期间进行了卵巢移位、子宫屏蔽，并使用了促性腺激素释放激素激动剂以保护卵巢功能。患者27岁时自然受孕。孕期顺利，患者足月行剖宫产分娩出一名健康新生儿。
总结与结论
通过多模式治疗及生育力保留的预处理干预可实现成功妊娠及分娩。
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