Stanić Gordana, Snežana Marinković, Ignjatović Dragana Ristić
Academy of Applied Studies Belgrade Department of School of Applied Health Sciences, Cara Dušana 254, Belgrade, Serbia.
Special Hospital for Thyroid Gland and Metabolism Disease Zlatibor, Kraljeve Vode 30, Zlatibor 31315, Serbia.
Iran J Public Health. 2022 Aug;51(8):1798-1806. doi: 10.18502/ijph.v51i8.10264.
Thyroid disorders are an area of public health concern worldwide. The study aimed to examine the incidence and severity of psychosomatic symptoms (distress, depression, anxiety and somatization) in patients with hypothyroidism, hyperthyroidism, Graves' disease and Hashimoto thyroiditis in relation to clinically healthy subjects.
This case control study was carried out from Feb to Jul 2019 in Serbia. Total sample consisted of 335 subjects, of both sex. The examined group included patients with thyroid disorders treated at the Special hospital for thyroid gland and metabolism disease. Control group included clinically healthy subjects. The Four Dimensional Symptom Questionnaire a self-assessment questionnaire for psychosomatic symptoms was the measuring instrument. Groups were compared using parametric (t-test) and nonparametric (Pearson chi-square test, Mann-Whitney U test, Kruskal-Wallis test) tests.
The incidence of all psychosomatic symptoms was high in patients with thyroid disease. Distress was found in 59.8% of the patients in the examined group comparing to the control group (12.8±8.2 vs. 8.9±8.1). The score of depression was twice higher in the examined group (2.05±2.99 vs. 1.23±2.47). Anxiety was present in 46.2% patients in the examined group, while somatization was found in 69.7% subjects. In hypothyroidism there was no difference between the examined and the control group regarding the level of anxiety, likewise with the level of depression in the control group and subjects with Graves' disease and Hashimoto thyroiditis.
Psychosomatic symptoms were significantly more severe in patients with thyroid disorders compared to the control group.
甲状腺疾病是全球公共卫生关注的领域。本研究旨在探讨甲状腺功能减退症、甲状腺功能亢进症、格雷夫斯病和桥本甲状腺炎患者与临床健康受试者相比，心身症状（痛苦、抑郁、焦虑和躯体化）的发生率和严重程度。
本病例对照研究于2019年2月至7月在塞尔维亚进行。总样本包括335名受试者，男女皆有。被检查组包括在甲状腺和代谢疾病专科医院接受治疗的甲状腺疾病患者。对照组包括临床健康受试者。使用《四维症状问卷》（一种心身症状自评问卷）作为测量工具。采用参数检验（t检验）和非参数检验（Pearson卡方检验、Mann-Whitney U检验、Kruskal-Wallis检验）对各组进行比较。
甲状腺疾病患者所有心身症状的发生率都很高。被检查组59.8%的患者存在痛苦，而对照组为12.8±8.2 vs. 8.9±8.1。被检查组的抑郁得分高出两倍（2.05±2.99 vs. 1.23±2.47）。被检查组46.2%的患者存在焦虑，69.7%的受试者存在躯体化。在甲状腺功能减退症患者中，被检查组与对照组在焦虑水平上没有差异，对照组与格雷夫斯病和桥本甲状腺炎患者在抑郁水平上也没有差异。
与对照组相比，甲状腺疾病患者的心身症状明显更严重。
