Wang Yang, Wang Dan, Chu Chao, Mu Jian-Jun, Wang Man, Liu Fu-Qiang, Xie Bing-Qing, Yang Fan, Dong Zhen-Zhen, Yuan Zu-Yi
Cardiology. 2015;130(4):242-8. doi: 10.1159/000371794.
The aim of our study was to assess the effects of altered salt and potassium intake on urinary renalase and serum dopamine levels in humans.
Forty-two subjects (28–65 years of age) were selected from a rural community of northern China. All subjects were sequentially maintained on a low-salt diet for 7 days (3.0 g/day of NaCl), a high-salt diet for an additional 7 days (18.0 g/day of NaCl), and a high-salt diet with potassium supplementation for a final 7 days (18.0 g/day of NaCl + 4.5 g/day of KCl).
Urinary renalase excretions were significantly higher during the high-salt diet intervention than during the low-salt diet. During high-potassium intake, urinary renalase excretions were not significantly different from the high-salt diet, whereas they were significantly higher than the low-salt levels. Serum dopamine levels exhibited similar trends across the interventions. Additionally, a significant positive relationship was observed between the urine renalase and serum dopamine among the different dietary interventions. Also, 24-hour urinary sodium excretion positively correlated with urine renalase and serum dopamine in the whole population.
The present study indicates that dietary salt intake and potassium supplementation increase urinary renalase and serum dopamine levels in Chinese subjects.
我们研究的目的是评估改变盐和钾摄入量对人体尿肾酶和血清多巴胺水平的影响。
从中国北方一个农村社区选取42名受试者（年龄在28 - 65岁之间）。所有受试者依次接受为期7天的低盐饮食（氯化钠3.0克/天），随后再接受为期7天的高盐饮食（氯化钠18.0克/天），最后接受为期7天的高盐饮食并补充钾（氯化钠18.0克/天 + 氯化钾4.5克/天）。
高盐饮食干预期间的尿肾酶排泄量显著高于低盐饮食期间。在高钾摄入期间，尿肾酶排泄量与高盐饮食期间无显著差异，但显著高于低盐水平。血清多巴胺水平在各干预期间呈现相似趋势。此外，在不同饮食干预中，尿肾酶与血清多巴胺之间存在显著正相关。而且，在整个人群中，24小时尿钠排泄量与尿肾酶和血清多巴胺呈正相关。
本研究表明，饮食中盐的摄入量和钾的补充会增加中国受试者的尿肾酶和血清多巴胺水平。
