Liu Fuqiang, Mu Jianjun, Yuan Zuyi, Zhang Min, Zheng Shuhui, Lian Qiufang, Liu Enqi, Xu Haixia, Ren Keyu, Huang Qiang
Department of Cardiovascular Medicine, First Affiliated Hospital of Medical College, Xi'an, PR China.
Acta Cardiol. 2011 Oct;66(5):635-9. doi: 10.1080/ac.66.5.2131090.
Dietary high salt or low potassium is always associated with an increased incidence of death or cardiovascular complications, but the mechanisms remain elusive. We hypothesize that haemostatic abnormalities may play an important role in the phenomenon.
Twenty normotensive subjects (aged 25 to 50 years) were selected from a rural community of Northern China. All of the people were sequentially maintained on a 3-day baseline investigation, 7 days on a low-salt diet (51.3 mmol or 3 g of NaCI per day), 7 days on a high-salt diet (307.7 mmol or 18 g of NaCl per day), and another 7 days on a high-salt diet with potassium supplementation (4.5 g/day, KCI). The concentrations of fibrinogen, D-dimer and von Willebrand factor (vWF) in plasma were assessed, and these data represent the systemic haemostatic state.
Plasma levels of fibrinogen, fibrin D-dimer and vWF were significantly higher in the high-salt diet than in the low-salt diet (P < 0.05). In contrast, potassium supplement could convert the sodium-dependent haemostatic abnormalities to normal (P < 0.05).
Dietary high salt intake could stimulate the production of haemostatic factors, which may ultimately lead to cardiovascular events. Inversely, potassium supplementation could ameliorate the sodium-induced haemostatic abnormalities.
饮食高盐或低钾总是与死亡或心血管并发症发生率增加相关，但机制仍不清楚。我们推测止血异常可能在该现象中起重要作用。
从中国北方一个农村社区选取20名血压正常的受试者（年龄25至50岁）。所有人依次接受为期3天的基线调查，7天的低盐饮食（每天51.3毫摩尔或3克氯化钠），7天的高盐饮食（每天307.7毫摩尔或18克氯化钠），以及另外7天的高盐饮食并补充钾（每天4.5克，氯化钾）。评估血浆中纤维蛋白原、D - 二聚体和血管性血友病因子（vWF）的浓度，这些数据代表全身止血状态。
高盐饮食组血浆纤维蛋白原、纤维蛋白D - 二聚体和vWF水平显著高于低盐饮食组（P < 0.05）。相反，补充钾可使钠依赖性止血异常恢复正常（P < 0.05）。
饮食高盐摄入可刺激止血因子的产生，这可能最终导致心血管事件。相反，补充钾可改善钠诱导的止血异常。
