Xu Qiu-Xiang, Zhang Zhen-Yu
Department of Obstetrics and Gynecology, Beijing Chaoyang Hospital, Affiliated to Capital Medical University, Beijing, China E-mail :
Asian Pac J Cancer Prev. 2015;16(6):2193-7. doi: 10.7314/apjcp.2015.16.6.2193.
Cervical cancer, mostly progressing from cervical intraepithelial neoplasia, is a major cause of morbidity and mortality in Chinese women. This is largely due to high prevalence of high-risk human papillomaviruses (hr-HPVs) in the population. The prevalence of hr-HPV DNA in women and in cervical lesions women ranged from 9.9% to 17.% and from 50.5% to 70.9% in different regions of China, respectively. The most common genotypes somewhat differ between regions throughout the country and from those in many other countries. This may be a challenge to cervical cancer screening and prevention in China. Combined detection of particular HPV genotypes should be recommended in all geographical regions in China and greater attention must be paid to specific hr-HPV types during cervical cancer screening and follow-up of cervical lesions. Besides, vaccination for prevention of cervical cancer by particular HPV genotypes, has not been introduced to China so far. Updated knowledge on prevalent HPV genotypes should be provided to public health organizations to help with the development of more effective HPV vaccines, which can protect Chinese women against HPV types prevalent in local China and thus have a substantial impact on the cervical cancer burden.
宫颈癌大多由宫颈上皮内瘤变发展而来，是中国女性发病和死亡的主要原因。这主要归因于人群中高危型人乳头瘤病毒（hr-HPVs）的高流行率。在中国不同地区，女性及宫颈病变女性中hr-HPV DNA的流行率分别为9.9%至17.%和50.5%至70.9%。全国不同地区最常见的基因型与许多其他国家的有所不同。这可能给中国的宫颈癌筛查和预防带来挑战。在中国所有地理区域均应推荐联合检测特定的HPV基因型，在宫颈癌筛查及宫颈病变随访过程中必须更加关注特定的hr-HPV类型。此外，针对特定HPV基因型预防宫颈癌的疫苗目前尚未引入中国。应向公共卫生组织提供关于流行HPV基因型的最新知识，以帮助研发更有效的HPV疫苗，从而保护中国女性免受中国本土流行的HPV类型感染，进而对宫颈癌负担产生重大影响。
