Kanamori Y, Nakazawa S, Kitoh J, Hoshino M
Second Department of Internal Medicine, Nagoya University School of Medicine, Japan.
Cell Tissue Res. 1989 Nov;258(2):365-71. doi: 10.1007/BF00239456.
The distribution of endocrine cells in the gastrointestinal tract of the house musk shrew, Suncus murinus (Family Soricidae, Order Insectivora) was studied immunohistochemically. The hormones investigated were gastrin, cholecystokinin (CCK), somatostatin, secretin, glucagon, gastric inhibitory polypeptide (GIP), motilin and neurotensin. In the gastric mucosa, gastrin and somatostatin cells were only found in the pyloric regions, and no other hormonal cell-types were observed. In the intestinal mucosa, the largest number of endocrine cells belonged to the gastrin and glucagon/glicentin cell-types, whereas CCK-33/39 and secretin cells were the least numerous. Numbers of other cell-types were intermediate between these two groups. The gastrin and GIP cells were mostly localized in the proximal portion of the intestine, decreasing in number towards the distal portion. The motilin and CCK-33/39 cells were restricted to the proximal half. The glucagon/glicentin and neurotensin cells were most abundant in the middle portion. The somatostatin and secretin cells, although only present in small numbers, were randomly distributed throughout the intestine. This characteristic distribution of gastrointestinal endocrine cells is discussed in comparison with the distribution patterns of other mammals.
采用免疫组织化学方法研究了臭鼩（食虫目鼩鼱科）胃肠道内分泌细胞的分布。所研究的激素包括胃泌素、胆囊收缩素（CCK）、生长抑素、促胰液素、胰高血糖素、胃抑制多肽（GIP）、胃动素和神经降压素。在胃黏膜中，胃泌素和生长抑素细胞仅见于幽门区，未观察到其他激素细胞类型。在肠黏膜中，数量最多的内分泌细胞属于胃泌素和胰高血糖素/胰高血糖素原细胞类型，而CCK-33/39和促胰液素细胞数量最少。其他细胞类型的数量介于这两组之间。胃泌素和GIP细胞主要位于肠的近端部分，向远端数量减少。胃动素和CCK-33/39细胞局限于近端半部。胰高血糖素/胰高血糖素原和神经降压素细胞在中部最为丰富。生长抑素和促胰液素细胞虽然数量较少，但随机分布于整个肠道。本文将这种胃肠道内分泌细胞的特征性分布与其他哺乳动物的分布模式进行了比较讨论。
