Kitamura N, Yamada J, Calingasan N Y, Yamashita T
Equine Vet J. 1984 Mar;16(2):103-7. doi: 10.1111/j.2042-3306.1984.tb01870.x.
Endocrine cells immunoreactive for somatostatin, gastrin, glicentin, glucagon, secretin, cholecystokinin, motilin and neurotensin were identified immunocytochemically in the gastrointestinal mucosa of the horse. Somatostatin-, glicentin- and glucagon-immunoreactive cells were very numerous in the cardiac and fundic regions of the stomach, whereas most gastrin-immunoreactive cells were confined to the pyloric region. Somatostatin-immunoreactive cells also were detected in all portions of the small intestine while gastrin-immunoreactive cells were confined exclusively to the upper portion and glicentin-immunoreactive cells were limited to the lower portions of the small intestine. Secretin-, cholecystokinin- and motilin-immunoreactive cells were observed only in the duodenum, while neurotensin-immunoreactive cells were confined primarily to the ileum. In the large intestine, somatostatin- and glicentin-immunoreactive cells were detected in the colon and rectum. The preferential location of endocrine cells provides additional information for future studies on the physiological roles of gastrointestinal peptides in the gastrointestinal tract of the horse.
通过免疫细胞化学方法在马的胃肠道黏膜中鉴定出了对生长抑素、胃泌素、胰高血糖素样肽、胰高血糖素、促胰液素、胆囊收缩素、胃动素和神经降压素呈免疫反应的内分泌细胞。生长抑素、胰高血糖素样肽和胰高血糖素免疫反应阳性细胞在胃的贲门和胃底部区域非常多，而大多数胃泌素免疫反应阳性细胞局限于幽门区域。生长抑素免疫反应阳性细胞也在小肠的所有部分被检测到，而胃泌素免疫反应阳性细胞仅局限于小肠上部，胰高血糖素样肽免疫反应阳性细胞局限于小肠下部。促胰液素、胆囊收缩素和胃动素免疫反应阳性细胞仅在十二指肠中观察到，而神经降压素免疫反应阳性细胞主要局限于回肠。在大肠中，生长抑素和胰高血糖素样肽免疫反应阳性细胞在结肠和直肠中被检测到。内分泌细胞的优先定位为未来研究胃肠道肽在马胃肠道中的生理作用提供了额外信息。
