Scherini E, Bernocchi G
Dipartimento di Biologia Animale, Universita di Pavia, Italy.
Cell Tissue Res. 1989 Nov;258(2):437-9. doi: 10.1007/BF00239466.
Intensely stained cells are found in the cerebellar white matter of the vermis and paravermis in adult rats after immunoreaction with an immune serum raised against glutamic acid decarboxylase (GAD). The cells are similar in size to cortical Purkinje cells and three times the size of Golgi cells of the internal granule layer, and have a thick immunopositive cell process emerging from a well-defined cytoplasmic cone. In the cytoplasm, immunoprecipitates are more dense around the nucleus as in normally located Purkinje cells. The morphological appearance of the immunopositive cells suggests that they may be ectopically located Purkinje cells. The soma of the ectopic Purkinje cells is contacted by a few darkly stained terminal boutons. Data indicate that, in spite of the different cellular environment, ectopic Purkinje cells can develop not only the typical morphological pattern already described but also other intrinsic features, such as their typical inhibitory neurotransmitter.
用抗谷氨酸脱羧酶（GAD）免疫血清进行免疫反应后，在成年大鼠蚓部和旁蚓部的小脑白质中发现了强染色细胞。这些细胞大小与皮质浦肯野细胞相似，是内颗粒层高尔基细胞大小的三倍，并且有一个从明确的细胞质锥发出的厚免疫阳性细胞突起。在细胞质中，免疫沉淀物在细胞核周围比正常位置的浦肯野细胞更密集。免疫阳性细胞的形态外观表明它们可能是异位的浦肯野细胞。异位浦肯野细胞的胞体与一些深色染色的终末小体接触。数据表明，尽管细胞环境不同，异位浦肯野细胞不仅可以发育出已经描述的典型形态模式，还可以发育出其他内在特征，例如其典型的抑制性神经递质。
