Tinoco-Araujo J E, Orti-Raduan E S L, Santos D, Colturato V A R, Souza M P, Mauad M A, Saggioro T C M, Bastos R S, da Silva Santos P S
Potiguar University, Laureate International Universities, Av. Sen Salgado Filho, 1610, Natal, 59056-000, Brazil.
Raul Bauab Educational Foundation, Jau, Brazil.
Clin Oral Investig. 2015 Dec;19(9):2345-9. doi: 10.1007/s00784-015-1464-x. Epub 2015 Apr 1.
This study was planned to evaluate the impact of oral health on the quality of life (QoL) of patients undergoing hematopoietic stem cell transplantation (HSCT).
We assessed 200 patients divided into two paired groups: 100 patients prior to HSCT (SG) and 100 healthy volunteers (CG). We applied the Oral Health Impact Profile instrument, which is based on the biopsychosocial problem gradation of World Health Organization (WHO) and relates oral health problems with QoL according to seven dimensions.
Fourteen patients in SG were referred for extraction of one to eight teeth, mostly due to deep caries with risk of pulpal infection and possible spread of infection via blood (r = 0.59, p = 0.000). The presence of severely compromised teeth by extensive decay correlated with Oral Health Impact Profile (OHIP-14). The Mann-Whitney test showed a significant difference between SG and CG in the following dimensions: functional limitation (p < 0.001), physical pain (p = 0.025), physical disability (p = 0.016), and social disability (p = 0.01).
The impact of oral health on QoL of onco-hematologic patients is weak but is greater as compared to healthy ones. Nevertheless, a significant impact is seen in patients with severely compromised teeth.
The negligence of oral care, proper hygiene, and the search for dental care may increase the risk for local and systemic infections.
本研究旨在评估口腔健康对接受造血干细胞移植（HSCT）患者生活质量（QoL）的影响。
我们评估了200名患者，分为两组配对组：100名HSCT术前患者（SG）和100名健康志愿者（CG）。我们应用了口腔健康影响量表，该量表基于世界卫生组织（WHO）的生物心理社会问题分级，并根据七个维度将口腔健康问题与生活质量相关联。
SG组中有14名患者被转诊拔除1至8颗牙齿，主要原因是深龋有牙髓感染风险以及可能通过血液传播感染（r = 0.59，p = 0.000）。广泛龋坏导致牙齿严重受损与口腔健康影响量表（OHIP - 14）相关。曼 - 惠特尼检验显示SG组和CG组在以下维度存在显著差异：功能受限（p < 0.001）、身体疼痛（p = 0.025）、身体残疾（p = 0.016）和社会残疾（p = 0.01）。
口腔健康对肿瘤血液科患者生活质量的影响较弱，但与健康人相比更大。然而，牙齿严重受损的患者会受到显著影响。
忽视口腔护理、适当的卫生措施以及寻求牙科护理可能会增加局部和全身感染的风险。
