Min Peiru, Xi Wenjing, Grassetti Luca, Trisliana Perdanasari Aurelia, Torresetti Matteo, Feng Shaoqing, Su Weijie, Pu Zheming, Zhang Yan, Han Sheng, Zhang Yi Xin, Di Benedetto Giovanni, Lazzeri Davide
Drs Min, Xi, and Trisliana Perdanasari are Residents, Drs Feng and Su are Attending Surgeons, Profs Pu and Y Zhang are Associate Professors, and Prof YX Zhang is a Professor and Assistant Chief of the Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China. Prof YX Zhang is also Chief of the Division of Reconstructive Microsurgery. Dr Grassetti is a Consultant Plastic Surgeon, Dr Torresetti is a Resident, and Prof Di Benedetto is a Professor and Chief of the Department of Plastic and Reconstructive Surgery, Marche Polytechnic University Medical School, University Hospital of Ancona, Ancona, Italy. Dr Han is a Plastic Surgeon in private practice in Shanghai, China. Dr Lazzeri is a Plastic Surgeon in private practice, Villa Salaria Clinic, Rome, Italy.
Aesthet Surg J. 2015 Jul;35(5):600-10. doi: 10.1093/asj/sju150. Epub 2015 Mar 29.
Research has investigated the decrease in human skin sebum after the application of botulinum toxin. Few studies of the mechanism and objective assessments of this phenomenon have been conducted and the correlation between the sebum production and injection dosages or techniques remains unclear.
We prospectively investigated the sebum regulation and its gradient around the injection site in patients who received intramuscular injections of botulinum toxin A (BTX-A) for forehead rhytides, comparing two injection doses.
Forty-two female volunteers with rhytides on the forehead region were randomly assigned to receive 10 or 20 units of BTX-A, which was administered in five standard injection sites. The baseline and post-treatment sebum production was measured using a Sebumeter.
Treatment with BTX-A exhibited significant sebum alteration at the injection site of both groups, with a sebum gradient surrounding the injection point. The efficacy did not improve at higher injection doses, with the four-unit regimen generally not being more potent than the two-unit regimen. The sebum production recovered to normal levels at the 16 week follow-up for both treatment groups, indicating that a higher dosage (four units) did not result in a longer duration until relapse compared with the two-unit dose.
We determined that the sebum production has a positive correlation with the distance away from the injection point. Intramuscular injection of BTX-A significantly reduces sebum production at the injection site but increases the sebum production of the surrounding skin at a radius of 2.5 cm at the 2, 4, and 8 week follow-ups.
2 Therapeutic.
已有研究探讨了肉毒杆菌毒素应用后人体皮肤皮脂的减少情况。但针对这一现象的机制及客观评估的研究较少，皮脂分泌与注射剂量或技术之间的相关性仍不明确。
我们前瞻性地研究了接受肉毒杆菌毒素A（BTX-A）肌内注射治疗额部皱纹的患者皮脂调节情况及其在注射部位周围的梯度变化，并比较了两种注射剂量。
42名前额部有皱纹的女性志愿者被随机分为两组，分别接受10单位或20单位的BTX-A，在五个标准注射部位进行注射。使用皮脂测定仪测量基线及治疗后的皮脂分泌情况。
两组患者注射部位的BTX-A治疗均显示出明显的皮脂改变，注射点周围存在皮脂梯度。高注射剂量时疗效并未改善，四单位方案总体上并不比两单位方案更有效。两个治疗组在16周随访时皮脂分泌均恢复至正常水平，表明与两单位剂量相比，较高剂量（四单位）并不会导致复发时间延长。
我们确定皮脂分泌与距注射点的距离呈正相关。肌内注射BTX-A可显著降低注射部位的皮脂分泌，但在2、4和8周随访时，会增加注射点周围半径2.5 cm范围内皮肤的皮脂分泌。
2级治疗性。
