Min Peiru, Zhang Zheng, Grassetti Luca, Perdanasari Aurelia Trisliana, Torresetti Matteo, Pu Zheming, Zhang Yan, Han Sheng, Marsili Riccardo, Zhang Yi Xin, di Benedetto Giovanni, Lazzeri Davide
Department of Plastic and Reconstructive Surgery, Shanghai Ninth People's Hospital, Shanghai JiaoTong University School of Medicine, Shanghai, China.
Department of Plastic and Reconstructive Surgery, Marche Polytechnic University Medical School, University Hospital of Ancona, Ancona, Italy.
Aesthetic Plast Surg. 2016 Jun;40(3):410-20. doi: 10.1007/s00266-016-0629-6. Epub 2016 Mar 4.
Although application of botulinum toxin type A (BTX-A) for the treatment of forehead rhytides has become very popular, the effects of its intramuscular injections on the skin mechanical properties remain unclear.
We prospectively investigated the alterations in the mechanical properties of the skin of patients who received intramuscular injections of botulinum toxin A (BTX-A) for forehead rhytides and compared two injection doses.
Of the 42 enrolled patients, one randomly assigned half received intramuscular injections of two units (group I), and the other half received four units (group II) of BTX-A in each injection point. The baseline and post-treatment skin mechanical parameters, including gross elasticity (R2), net elasticity (R5), viscoelastic ratio (R6) and biological elasticity (R7), were measured using the Cutometer(®) and compared.
Treatment with BTX-A resulted in significant overall alterations in the mechanical properties of skin at the injection sites of both treatment groups during the 16-week period, and no significant differences were observed between groups. Significant decreases in biological elasticity, net elasticity and viscoelasticity properties were observed at 2 weeks follow-up and began to recover at that time. All of the skin mechanical properties recovered to baseline levels by 16 weeks of follow-up in both dosage groups, which indicates that the higher dosage (4 units) did not delay relapse compared to the two-unit dosage.
We concluded that intramuscular injections of BTX-A significantly regulated the gross elasticity, net elasticity, functional elasticity and viscoelastic elasticity at the injection point over a radius of 1.5 cm at 2, 4 and 8 weeks follow-up. The alteration in the skin measurements had completely diminished by the 16-week follow-up.
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尽管A型肉毒毒素（BTX-A）用于治疗额部皱纹已非常普遍，但其肌肉注射对皮肤力学性能的影响仍不清楚。
我们前瞻性地研究了接受肌肉注射A型肉毒毒素（BTX-A）治疗额部皱纹患者皮肤力学性能的变化，并比较了两种注射剂量。
42名入选患者中，随机分配一半在每个注射点接受2单位的肌肉注射（I组），另一半接受4单位（II组）的BTX-A注射。使用皮肤弹性测量仪测量基线和治疗后的皮肤力学参数，包括总弹性（R2）、净弹性（R5）、粘弹性比（R6）和生物弹性（R7），并进行比较。
在16周期间，BTX-A治疗使两个治疗组注射部位皮肤的力学性能发生了显著的总体变化，两组之间未观察到显著差异。在随访2周时观察到生物弹性、净弹性和粘弹性显著下降，并在此时开始恢复。两个剂量组在随访16周时所有皮肤力学性能均恢复到基线水平，这表明与2单位剂量相比，较高剂量（4单位）并未延迟复发。
我们得出结论，肌肉注射BTX-A在随访2、4和8周时显著调节了注射点周围1.5 cm半径范围内的总弹性、净弹性、功能弹性和粘弹性。到随访16周时，皮肤测量值的变化已完全消失。
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