Zhang H
Zhonghua Bing Li Xue Za Zhi. 1989 Jun;18(2):137-9.
Nuclear DNA content was determined by flow cytometry in biopsy samples taken from cervical carcinomas of 33 patients. Aneuploid DNA content was found in 24 cases (72.7%). The relationship between DNA content of carcinoma cells and the clinicopathological features was investigated. Carcinomas with aneuploid DNA content were clinically more advanced and histologically poorly differentiated as compared with those with diploid DNA content. DNA content was found neither correlated with the patient's age nor with the growing type of the tumor; and analysis of DNA content by flow cytometry was considered helpful in evaluating tumor malignancy, efficacy of treatment and prognosis.
采用流式细胞术对33例宫颈癌患者活检标本的核DNA含量进行测定。24例(72.7%)检测到非整倍体DNA含量。研究了癌细胞DNA含量与临床病理特征之间的关系。与二倍体DNA含量的癌相比,非整倍体DNA含量的癌在临床上分期更晚,组织学上分化更差。发现DNA含量与患者年龄及肿瘤生长类型均无相关性;并且认为通过流式细胞术分析DNA含量有助于评估肿瘤恶性程度、治疗效果及预后。