Behera Vineet, Randive Makarand, Sharma Praveen, Nair Velu
Department of Internal Medicine, Armed Forces Medical College, Pune, 411040 India.
Indian J Hematol Blood Transfus. 2015 Jun;31(2):297-9. doi: 10.1007/s12288-014-0461-6. Epub 2014 Oct 14.
Megaloblastic anemia (MA) is a common disorder with varied manifestations. It generally results in mild to moderate splenomegaly which is due to sequestration of macrocytic erythrocytes in spleen. Massive splenomegaly is generally seen in infections, myeloproliferative diseases, neoplasms, storage disorders or hematological conditions; but is not heard of and has rarely been reported in MA. We discuss a case of massive splenomegaly who presented with symptomatic anemia and was found to have MA. He was extensive evaluated for all other causes of massive splenomegaly which was normal. Further, after a therapeutic trial of MA he showed a regression in spleen size confirming that the massive splenomegaly was attributable to MA.
巨幼细胞贫血（MA）是一种具有多种表现的常见病症。它通常会导致轻度至中度脾肿大，这是由于脾脏中巨噬红细胞的滞留所致。巨大脾肿大一般见于感染、骨髓增殖性疾病、肿瘤、贮积病或血液系统疾病；但在巨幼细胞贫血中未听说过，也很少有报道。我们讨论一例以症状性贫血就诊且被发现患有巨幼细胞贫血的巨大脾肿大病例。对该患者进行了全面评估，以查找所有其他导致巨大脾肿大的病因，结果均正常。此外，在对巨幼细胞贫血进行治疗性试验后，他的脾脏大小有所缩小，证实巨大脾肿大归因于巨幼细胞贫血。
