Gholipur-Shahraki Tahereh, Sadeghi Alireza, Oghab Padideh, Farrokhi Pegah, Moghaddas Azadeh
Department of Clinical Pharmacy, Isfahan University of Medical Sciences, Isfahan, Iran.
Department of Internal Medicine, Faculty of Medicine, Isfahan University of Medical Sciences, Isfahan, Iran.
Int J Hematol Oncol Stem Cell Res. 2021 Apr 1;15(2):132-134. doi: 10.18502/ijhoscr.v15i2.6044.
Megaloblastic anemia is a common disorder with various manifestations. Of the many causes, cobalamin or folate deficiency can eventuate into megaloblastic anemia. It can lead to pancytopenia and mild to moderate splenomegaly, but massive splenomegaly rarely seen in this situation. We describe a 39-year-old woman with marked enlargement of the spleen and pancytopenia that was found to have megaloblastic anemia. The splenomegaly and blood count resolved 4 months after initiation of vitamin B therapy. It is important to know massive splenomegaly may occur in megaloblastic anemia, and although it is rare, bur can reversible with early treatment.
巨幼细胞贫血是一种具有多种表现的常见病症。在众多病因中，钴胺素或叶酸缺乏可导致巨幼细胞贫血。它可引起全血细胞减少和轻至中度脾肿大，但在这种情况下很少见到巨大脾肿大。我们描述了一名39岁女性，其脾脏明显肿大且全血细胞减少，被诊断为巨幼细胞贫血。在开始维生素B治疗4个月后，脾肿大和血细胞计数恢复正常。重要的是要知道巨幼细胞贫血可能会出现巨大脾肿大，虽然罕见，但早期治疗可使其逆转。
