冠状动脉狭窄：慢性肾脏损伤的新危险因素？

Coronary artery stenosis: a new risk factor for chronic kidney injury?

机构信息

Department of Nephrology, Medical Faculty, Heinrich Heine University, Düsseldorf, Germany.

出版信息

Kidney Int. 2015 Apr;87(4):676-7. doi: 10.1038/ki.2014.431.

DOI:10.1038/ki.2014.431

Abstract

Coronary artery stenosis induces renal inflammation and kidney injury in pigs even in the absence of myocardial infarction or clinically significant heart failure. This effect is aggravated by experimentally induced renovascular hypertension. Interestingly, oxidative stress originating from the ischemic myocardium was identified as a possible mediator of this new pathophysiological link between heart and kidney. Renin-angiotensin or sympathetic nervous system activation did not appear to play a role in the observed cardio-renal link.

摘要

冠状动脉狭窄即使在没有心肌梗死或临床显著心力衰竭的情况下，也会导致猪的肾脏炎症和损伤。实验性诱导的肾血管性高血压会加重这种影响。有趣的是，来自缺血性心肌的氧化应激被认为是心脏和肾脏之间这种新的病理生理联系的一个可能的介导者。肾素-血管紧张素或交感神经系统的激活似乎在观察到的心肾联系中不起作用。