Zuĭkov S A
Adv Gerontol. 2014;27(3):463-7.
The interrelation of purine nucleotides with antioxidant system in blood plasma and erythrocytes depending on age, as well as the contribution of the key enzymes of purine decomposition to the formation of reactive oxygen metabolites were studied. 50 conditionally healthy people aged 40-79 years were examined. Increase in all indicators of pro-oxidant system of blood plasma with age was determined. Statistically significant interrelations between the studied parameters and age of the examined persons were determined in the blood plasma. The relationship between the glutathione peroxidase and adenosine deaminase/xanthine oxidase, adenosine deaminase and xanthine oxidase was also determined. A significant increase of products of oxidative proteins modification in plasma and erythrocytes with aging was discovered. Reduction with age of key enzymes of antioxidant protection--superoxide dismutase and glutathione peroxidase in blood plasma and erythrocytes was determined. The data obtained indicate that with age there is an imbalance in the antioxidant system in blood plasma and erythrocytes contributing to the development of pathological conditions by increasing oxidative stress, which is greatly manifested while aging.
研究了嘌呤核苷酸与血浆和红细胞中抗氧化系统的相互关系（取决于年龄），以及嘌呤分解关键酶对活性氧代谢产物形成的贡献。对50名40 - 79岁的健康状况正常的人进行了检查。确定了血浆促氧化系统的所有指标随年龄增长而增加。在血浆中确定了所研究参数与受检者年龄之间具有统计学意义的相互关系。还确定了谷胱甘肽过氧化物酶与腺苷脱氨酶/黄嘌呤氧化酶、腺苷脱氨酶与黄嘌呤氧化酶之间的关系。发现随着衰老，血浆和红细胞中氧化蛋白质修饰产物显著增加。确定了血浆和红细胞中抗氧化保护关键酶——超氧化物歧化酶和谷胱甘肽过氧化物酶随年龄增长而减少。所获得的数据表明，随着年龄增长，血浆和红细胞中的抗氧化系统失衡，通过增加氧化应激导致病理状况的发展，而这在衰老过程中表现得尤为明显。
