Pan Wei, Sun Qian, Wang Yang, Wang Jian, Cao Shui, Ren Xiubao
Department of immunology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, 300060, China.
Tumour Biol. 2015 May;36(5):3159-69. doi: 10.1007/s13277-015-3363-9. Epub 2015 Apr 1.
The hallmark of tumor microenvironment is that it makes up of numerous immunomodulatory cells and factors which exert essential roles in immunoprotection and immunosuppression in addition to tumor cells. Myeloid-derived suppressor cells (MDSCs) are a heterogeneous population of immature myeloid cells reported to promote immunosuppression and angiogenesis and facilitate tumor metastasis and invasion. The wide scope of MDSCs functional activities make these cells promising targets for effective cancer treatments. In this review, we briefly discuss the origin, subpopulation, and functions of MDSCs, as well as the potential to target these cells for therapeutic benefit. We focus on the underlying molecular mechanisms of these drugs targeting MDSCs, mainly from the standpoint of molecules related to drug targets.
肿瘤微环境的标志在于，除肿瘤细胞外，它还由众多免疫调节细胞和因子组成，这些细胞和因子在免疫保护和免疫抑制中发挥着重要作用。髓系来源的抑制细胞（MDSCs）是一群异质性的未成熟髓系细胞，据报道它们可促进免疫抑制和血管生成，并促进肿瘤转移和侵袭。MDSCs广泛的功能活动使这些细胞成为有效癌症治疗的有希望的靶点。在本综述中，我们简要讨论了MDSCs的起源、亚群和功能，以及针对这些细胞以获得治疗益处的潜力。我们主要从与药物靶点相关的分子角度，关注这些靶向MDSCs的药物的潜在分子机制。
