Moscat Jorge, Richardson Adam, Diaz-Meco Maria T
Sanford-Burnham Medical Research Institute, La Jolla, CA 92037, USA.
Cell Res. 2015 May;25(5):537-8. doi: 10.1038/cr.2015.38. Epub 2015 Mar 31.
Efforts to identify new therapeutic targets in cancer primarily focused on oncogenes and tumor suppressor genes, and their mechanisms of action. However, there is an emerging alternative strategy that involves identification of target proteins that are not encoded by oncogenes, but are, nonetheless, required to accommodate cancer-specific stresses.
在癌症中识别新治疗靶点的努力主要集中在癌基因和肿瘤抑制基因及其作用机制上。然而，一种新出现的替代策略涉及识别并非由癌基因编码，但却是适应癌症特异性应激所必需的靶蛋白。
