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UDP-糖作为细胞外信号分子：P2Y14受体激活的细胞和生理后果

UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation.

作者信息

Lazarowski Eduardo R, Harden T Kendall

机构信息

Departments of Medicine (E.R.L.) and Pharmacology (T.K.H.), University of North Carolina School of Medicine, Chapel Hill, North Carolina.

Departments of Medicine (E.R.L.) and Pharmacology (T.K.H.), University of North Carolina School of Medicine, Chapel Hill, North Carolina

出版信息

Mol Pharmacol. 2015 Jul;88(1):151-60. doi: 10.1124/mol.115.098756. Epub 2015 Mar 31.

DOI:10.1124/mol.115.098756
PMID:25829059
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4468635/
Abstract

UDP-sugars, which are indispensable for protein glycosylation reactions in cellular secretory pathways, also act as important extracellular signaling molecules. We discuss here the broadly expressed P2Y14 receptor, a G-protein-coupled receptor targeted by UDP sugars, and the increasingly diverse set of physiologic responses discovered recently functioning downstream of this receptor in many epithelia as well as in immune, inflammatory, and other cells.

摘要

UDP-糖是细胞分泌途径中蛋白质糖基化反应所必需的，同时也作为重要的细胞外信号分子发挥作用。我们在此讨论广泛表达的P2Y14受体，这是一种受UDP-糖作用的G蛋白偶联受体，以及最近发现的在许多上皮细胞以及免疫、炎症和其他细胞中该受体下游发挥作用的越来越多样的生理反应。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6946/4468635/399e1f672ff4/mol.115.098756absf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6946/4468635/399e1f672ff4/mol.115.098756absf1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/6946/4468635/399e1f672ff4/mol.115.098756absf1.jpg

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