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P2Y₁₄ 的缺失导致对血液学应激的阻滞反应。

Loss of P2Y₁₄ results in an arresting response to hematological stress.

作者信息

Garrison Brian S, Rossi Derrick J

出版信息

J Clin Invest. 2014 Jul;124(7):2846-8. doi: 10.1172/JCI76626. Epub 2014 Jun 17.

DOI:10.1172/JCI76626
PMID:24937422
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4071389/
Abstract

The regenerative capacity of tissues to recover from injury or stress is dependent on stem cell competence, yet the underlying mechanisms that govern how stem cells detect stress and initiate appropriate responses are poorly understood. In this issue of the JCI, Cho and Yusuf et al. demonstrate that the purinergic receptor P2Y14 may mediate the hematopoietic stem and progenitor cell regenerative response.

摘要

组织从损伤或应激中恢复的再生能力取决于干细胞的功能，但目前对于干细胞如何检测应激并启动适当反应的潜在机制仍知之甚少。在本期《临床研究杂志》中，赵（Cho）和优素福（Yusuf）等人证明，嘌呤能受体P2Y14可能介导造血干细胞和祖细胞的再生反应。

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Loss of P2Y₁₄ results in an arresting response to hematological stress.P2Y₁₄ 的缺失导致对血液学应激的阻滞反应。
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The role of purinergic receptors in stem cell differentiation.嘌呤能受体在干细胞分化中的作用。
Comput Struct Biotechnol J. 2014 Nov 7;13:75-84. doi: 10.1016/j.csbj.2014.11.003. eCollection 2015.
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UDP-Sugars as Extracellular Signaling Molecules: Cellular and Physiologic Consequences of P2Y14 Receptor Activation.UDP-糖作为细胞外信号分子：P2Y14受体激活的细胞和生理后果
Mol Pharmacol. 2015 Jul;88(1):151-60. doi: 10.1124/mol.115.098756. Epub 2015 Mar 31.

本文引用的文献

1
Purinergic P2Y₁₄ receptor modulates stress-induced hematopoietic stem/progenitor cell senescence.嘌呤能P2Y₁₄受体调节应激诱导的造血干细胞/祖细胞衰老。
J Clin Invest. 2014 Jul;124(7):3159-71. doi: 10.1172/JCI61636. Epub 2014 Jun 17.
2
Quiescent hematopoietic stem cells accumulate DNA damage during aging that is repaired upon entry into cell cycle.静止的造血干细胞在衰老过程中积累DNA损伤，这些损伤在进入细胞周期时会被修复。
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Epigenomic profiling of young and aged HSCs reveals concerted changes during aging that reinforce self-renewal.年轻和衰老造血干细胞的表观基因组分析揭示了衰老过程中协同发生的、增强自我更新的变化。
Cell Stem Cell. 2014 May 1;14(5):673-88. doi: 10.1016/j.stem.2014.03.002.
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Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner.全身照射通过 Ink4a 和 Arf 非依赖性诱导 HSC 早衰导致长期的小鼠 BM 损伤。
Blood. 2014 May 15;123(20):3105-15. doi: 10.1182/blood-2013-07-515619. Epub 2014 Mar 12.
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Cellular senescence and its effector programs.细胞衰老及其效应程序。
Genes Dev. 2014 Jan 15;28(2):99-114. doi: 10.1101/gad.235184.113.
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Proliferation-dependent alterations of the DNA methylation landscape underlie hematopoietic stem cell aging.增殖依赖性的 DNA 甲基化景观改变是造血干细胞衰老的基础。
Cell Stem Cell. 2013 Apr 4;12(4):413-25. doi: 10.1016/j.stem.2013.01.017. Epub 2013 Feb 14.
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DNA damage checkpoints in stem cells, ageing and cancer.干细胞、衰老和癌症中的 DNA 损伤检查点。
Nat Rev Mol Cell Biol. 2012 Sep;13(9):579-90. doi: 10.1038/nrm3420.
8
Cdc42 activity regulates hematopoietic stem cell aging and rejuvenation.Cdc42 活性调节造血干细胞衰老和更新。
Cell Stem Cell. 2012 May 4;10(5):520-30. doi: 10.1016/j.stem.2012.04.007.
9
Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age.人类骨髓造血干细胞随着年龄的增长而频率增加，并偏向髓系。
Proc Natl Acad Sci U S A. 2011 Dec 13;108(50):20012-7. doi: 10.1073/pnas.1116110108. Epub 2011 Nov 28.
10
Clonal analysis reveals multiple functional defects of aged murine hematopoietic stem cells.克隆分析揭示了衰老的鼠造血干细胞的多种功能缺陷。
J Exp Med. 2011 Dec 19;208(13):2691-703. doi: 10.1084/jem.20111490. Epub 2011 Nov 21.