Kim Hwan Wook, Moon Mi Hyoung, Jo Keon Hyun, Song Hyun, Lee Jae Won
Department of Thoracic and Cardiovascular Surgery, Seoul St. Mary's Hospital, School of Medicine, The Catholic University of Korea, 505 Banpo-dong, Seocho-gu, Seoul, 137-701 Republic of Korea.
Department of Thoracic and Cardiovascular Surgery, Seoul Asan Hospital, School of Medicine, The University of Ulsan, 388-1 Pungnap-dong, Songpa-gu, Seoul, 138-736 Republic of Korea.
Indian J Surg. 2015 Feb;77(1):7-15. doi: 10.1007/s12262-012-0724-0. Epub 2012 Sep 14.
The present study was aimed to compare the left atrial and left ventricular diastolic functions amongst the rheumatic and degenerative mitral valve disease patients in atrial fibrillation who reverted to normal sinus rhythm following Cox-maze procedure. We prospectively investigated the left atrial and left ventricular function with Doppler echocardiography, by dividing into the rheumatic (N = 105) and the degenerative group (N = 47). Over the follow-up period (mean: 4.4 ± 1.2 years in the rheumatic group, 4.8 ± 1.3 years in the degenerative group), the rheumatic group showed statistically significant decrease in A' velocity and E' velocity, on contrary to degenerative group (A' velocity: mean decrease of 0.43 ± 0.13 cm/s in the rheumatic group, mean increase of 0.57 ± 0.11 cm/s in the degenerative group, p = 0.029, E' velocity: mean decrease of 0.23 ± 0.17 cm/s in the rheumatic group, mean increase of 0.21 ± 0.15 cm/s in the degenerative group, p = 0.031). In addition, the rheumatic group showed statistically significant increase in E/E' ratio than the degenerative group (mean increase of 4.49 ± 1.98 in the rheumatic group, mean increase of 1.74 ± 1.52 in the degenerative group, p = 0.047). Despite successful sinus rhythm restoration, the progressive loss of LA function as well as LV diastolic function is more prominent in the rheumatic group than the degenerative group. Therefore, differentiated strategies for postoperative surveillance are needed according to the pathology of mitral valve disease.
本研究旨在比较风湿性和退行性二尖瓣疾病患者在房颤状态下接受Cox迷宫手术后恢复正常窦性心律时的左心房和左心室舒张功能。我们通过多普勒超声心动图对左心房和左心室功能进行了前瞻性研究,将患者分为风湿性组(N = 105)和退行性组(N = 47)。在随访期间(风湿性组平均为4.4±1.2年,退行性组平均为4.8±1.3年),与退行性组相反,风湿性组的A'速度和E'速度出现统计学显著下降(A'速度:风湿性组平均下降0.43±0.13cm/s,退行性组平均增加0.57±0.11cm/s,p = 0.029;E'速度:风湿性组平均下降0.23±0.17cm/s,退行性组平均增加0.21±0.15cm/s,p = 0.031)。此外,风湿性组的E/E'比值比退行性组有统计学显著增加(风湿性组平均增加4.49±1.98,退行性组平均增加1.74±1.52,p = 0.047)。尽管成功恢复了窦性心律,但风湿性组左心房功能以及左心室舒张功能的逐渐丧失比退行性组更为突出。因此,需要根据二尖瓣疾病的病理情况制定不同的术后监测策略。