Hollander D, Tarnawski A, Stachura J, Gergely H
Division of Gastroenterology, University of California, Irvine 92717.
Dig Dis Sci. 1989 Nov;34(11):1692-700. doi: 10.1007/BF01540046.
We examined histologic and ultrastructural changes in the gastric mucosa of aging rats. Standardized gastric specimens from Sprague-Dawley rats 3 months of age (young) and 24 months of age (old) were evaluated by qualitative and quantitative histology and transmission electron microscopy. Old rats had the following histologic changes: (1) partial atrophy of the gastric glands and their replacement with hyalinlike connective tissue; (2) cystic dilatation of the gastric glands at the bases with occasional squamous cell metaplasia; and (3) extensive perivascular depositions of PAS-positive material, negative for amyloid. The total mucosal thickness was 484 +/- 100 microns in young rats vs 1122 +/- 240 microns in old rats (P less than 0.01). Electron microscopy demonstrated degenerative changes in parietal and chief cells, hyperplasia of surface and foveolar mucous cells, and prominent accumulation of disorganized collagen fibrils in perivascular connective tissue. This study indicates that the gastric mucosa of aging rats that have not been exposed to damaging agents does show definite histologic and ultrastructural changes.
我们研究了衰老大鼠胃黏膜的组织学和超微结构变化。对3月龄（年轻）和24月龄（年老）的Sprague-Dawley大鼠的标准化胃标本进行了定性和定量组织学以及透射电子显微镜评估。年老大鼠出现了以下组织学变化：（1）胃腺部分萎缩并被透明样结缔组织替代；（2）胃腺底部囊性扩张，偶见鳞状上皮化生；（3）血管周围有大量PAS阳性物质沉积，对淀粉样蛋白呈阴性。年轻大鼠的黏膜总厚度为484±100微米，年老大鼠为1122±240微米（P<0.01）。电子显微镜显示壁细胞和主细胞发生退行性变化，表面和小凹黏液细胞增生，血管周围结缔组织中无序胶原纤维显著积聚。本研究表明，未接触损伤因子的衰老大鼠胃黏膜确实出现了明确的组织学和超微结构变化。
