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横纹肌溶解症:发病机制、诊断与治疗

Rhabdomyolysis: pathogenesis, diagnosis, and treatment.

作者信息

Torres Patrick A, Helmstetter John A, Kaye Adam M, Kaye Alan David

机构信息

Department of Anesthesiology, Louisiana State University Health Sciences Center, New Orleans, LA.

Thomas J. Long School of Pharmacy, University of the Pacific, Stockton, CA.

出版信息

Ochsner J. 2015 Spring;15(1):58-69.

PMID:25829882
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4365849/
Abstract

BACKGROUND

Rhabdomyolysis is a complex medical condition involving the rapid dissolution of damaged or injured skeletal muscle.

METHODS

This review focuses on the epidemiology, pathophysiology, causes, presentation, diagnosis, complications, management, and anesthetic considerations related to rhabdomyolysis.

RESULTS

Any form of muscle damage--and by extension any entity that causes muscle damage--can initiate rhabdomyolysis. One of the most important treatment goals when rhabdomyolysis is suspected is avoiding acute kidney injury.

CONCLUSION

All clinicians should be aware of common causes, diagnosis, and treatment options.

摘要

背景

横纹肌溶解症是一种复杂的医学病症,涉及受损或受伤骨骼肌的快速溶解。

方法

本综述聚焦于与横纹肌溶解症相关的流行病学、病理生理学、病因、临床表现、诊断、并发症、治疗及麻醉注意事项。

结果

任何形式的肌肉损伤——进而任何导致肌肉损伤的因素——都可引发横纹肌溶解症。怀疑发生横纹肌溶解症时,最重要的治疗目标之一是避免急性肾损伤。

结论

所有临床医生都应了解其常见病因、诊断方法及治疗选择。

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本文引用的文献

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Paediatr Anaesth. 2013 Sep;23(9):855-64. doi: 10.1111/pan.12248. Epub 2013 Aug 6.
2
Cytochrome P450 drug interactions with statin therapy.细胞色素 P450 药物相互作用与他汀类药物治疗。
Singapore Med J. 2013 Mar;54(3):131-5. doi: 10.11622/smedj.2013044.
3
The controversies of statin therapy: weighing the evidence.他汀类药物治疗的争议:权衡证据。
J Am Coll Cardiol. 2012 Sep 4;60(10):875-81. doi: 10.1016/j.jacc.2012.07.007. Epub 2012 Aug 15.
4
Anaesthetic management in patients with Duchenne muscular dystrophy undergoing orthopaedic surgery: a review of 232 cases.杜氏肌营养不良症患者行骨科手术的麻醉管理:232 例回顾性研究
Eur J Anaesthesiol. 2012 Oct;29(10):489-94. doi: 10.1097/EJA.0b013e3283566789.
5
Exertional rhabdomyolysis: a clinical review with a focus on genetic influences.运动性横纹肌溶解症:一项聚焦遗传影响的临床综述
J Clin Neuromuscul Dis. 2012 Mar;13(3):122-36. doi: 10.1097/CND.0b013e31822721ca.
6
Clinical importance of the drug interaction between statins and CYP3A4 inhibitors: a retrospective cohort study in The Health Improvement Network.他汀类药物与 CYP3A4 抑制剂相互作用的临床重要性:在健康改善网络中的回顾性队列研究。
Pharmacoepidemiol Drug Saf. 2012 May;21(5):494-506. doi: 10.1002/pds.3199. Epub 2012 Mar 16.
7
Statin-induced myopathies.他汀类药物引起的肌病。
Pharmacol Rep. 2011;63(4):859-66. doi: 10.1016/s1734-1140(11)70601-6.
8
Statin myopathy: a common dilemma not reflected in clinical trials.他汀类药物相关性肌病:临床试验未反映的常见难题。
Cleve Clin J Med. 2011 Jun;78(6):393-403. doi: 10.3949/ccjm.78a.10073.
9
Early fluid resuscitation in patients with rhabdomyolysis.横纹肌溶解症患者的早期液体复苏。
Nat Rev Nephrol. 2011 May 17;7(7):416-22. doi: 10.1038/nrneph.2011.56.
10
Rhabdomyolysis: pathogenesis of renal injury and management.横纹肌溶解症:肾损伤的发病机制与管理
Pediatr Nephrol. 2011 Oct;26(10):1781-8. doi: 10.1007/s00467-010-1727-3. Epub 2011 Jan 20.