Riesgo Vincent J, Delgado Silvia R, Poveda Julio, Rammohan Kottil
1 Department of Neurology, University of Miami, Miami, FL 33136, USA ; 2 Department of Pathology, University of Miami/Jackson Memorial Hospital, Miami, FL, USA.
J Gastrointest Oncol. 2015 Apr;6(2):E16-20. doi: 10.3978/j.issn.2078-6891.2014.076.
Numb chin syndrome (NCS) can be a sign of malignancy. Its association with gastric adenocarcinoma is rare. We report a case of a 27-year-old Hispanic female that presented with complaint of left sided headache associated with numbness of the left side of chin and lower gingiva. Initial brain MRI, whole body gallium scan, high resolution CT of chest and elevated protein in the CSF were suggestive of sarcoidosis. She was treated with IV steroids with transient clinical improvement. Two weeks later, her symptoms worsened and further evaluation revealed the diagnosis of a poorly differentiated metastatic gastric adenocarcinoma with leptomeningeal involvement. This case report aims to emphasize the importance of identifying NCS as a possible indication of an underlying malignant condition. Reported cases of NCS associated with metastatic gastric adenocarcinoma are very rare.
麻木性下巴综合征(NCS)可能是恶性肿瘤的征兆。它与胃腺癌的关联较为罕见。我们报告一例27岁的西班牙裔女性病例,该患者主诉左侧头痛,并伴有左侧下巴和下牙龈麻木。最初的脑部磁共振成像(MRI)、全身镓扫描、胸部高分辨率计算机断层扫描(CT)以及脑脊液中蛋白质升高提示结节病。她接受了静脉注射类固醇治疗,临床症状有短暂改善。两周后,她的症状恶化,进一步检查发现诊断为低分化转移性胃腺癌伴软脑膜受累。本病例报告旨在强调识别NCS作为潜在恶性疾病可能指征的重要性。报道的与转移性胃腺癌相关的NCS病例非常罕见。