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导致涎腺导管腺癌诊断的麻木性颏部综合征:一例报告及文献复习

Numb Chin Syndrome Leading to a Diagnosis of Salivary Ductal Adenocarcinoma: A Case Report and Review of the Literature.

作者信息

Wu Lei, Zheng Yifan, Zhou Zhou, Liu Yanmei, Zhang Weixi, Wu Qi

机构信息

Department of Neurology, The First Affiliated Hospital, Sun Yat-sen University, Guangzhou, China.

出版信息

Front Neurol. 2017 Jul 25;8:343. doi: 10.3389/fneur.2017.00343. eCollection 2017.

DOI:10.3389/fneur.2017.00343
PMID:28790964
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC5526228/
Abstract

Numb chin syndrome (NCS) refers to a rare sensory neuropathy characterized by numbness of the chin within the distribution of the mental or inferior alveolar nerve. Although NCS is usually caused by a benign process, it should not be underestimated and a thorough diagnostic evaluation for a new or known progressive malignancy should always be performed. Here, we report a case of salivary ductal adenocarcinoma that mimicked a pulpitis and periodontitis in its early presentation accompanied by numbness of chin. The course and diagnosis of this case are discussed, and a brief review of the literature is presented. It is hoped for clinicians to keep the malignant possibility of NCS in mind and take a thorough examination.

摘要

麻木性颏综合征(NCS)是一种罕见的感觉神经病变,其特征为颏部在颏神经或下牙槽神经分布区域内出现麻木。尽管NCS通常由良性病变引起,但不应被低估,对于新发或已知的进行性恶性肿瘤应始终进行全面的诊断评估。在此,我们报告一例涎腺导管腺癌病例,该病例在早期表现为类似牙髓炎和牙周炎,并伴有颏部麻木。本文讨论了该病例的病程及诊断,并对相关文献进行了简要综述。希望临床医生牢记NCS的恶性可能性并进行全面检查。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c7/5526228/d37e053d2af3/fneur-08-00343-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c7/5526228/2b83a105146b/fneur-08-00343-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c7/5526228/4dd8e1eddbe6/fneur-08-00343-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c7/5526228/ae2facd5c019/fneur-08-00343-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c7/5526228/ed208d720b60/fneur-08-00343-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c7/5526228/d37e053d2af3/fneur-08-00343-g005.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c7/5526228/2b83a105146b/fneur-08-00343-g001.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c7/5526228/4dd8e1eddbe6/fneur-08-00343-g002.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c7/5526228/ae2facd5c019/fneur-08-00343-g003.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c7/5526228/ed208d720b60/fneur-08-00343-g004.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/45c7/5526228/d37e053d2af3/fneur-08-00343-g005.jpg

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Numb chin syndrome associated with vertical root fracture and odontogenic infection.与垂直根折及牙源性感染相关的颏部感觉异常综合征
Quintessence Int. 2017;48(3):225-230. doi: 10.3290/j.qi.a37643.
2
Numb chin syndrome as a sign of mandibular metastasis: A case report.麻木性颏部综合征作为下颌骨转移的征象:一例报告。
Int J Surg Case Rep. 2017;31:68-71. doi: 10.1016/j.ijscr.2017.01.001. Epub 2017 Jan 4.
3
Numb chin syndrome: A harbinger of tumor progression or relapse.麻木性颏部综合征:肿瘤进展或复发的先兆。
Am J Emerg Med. 2017 May;35(5):805.e1-805.e2. doi: 10.1016/j.ajem.2016.11.055. Epub 2016 Dec 1.
4
Bilateral Numb Chin Syndrome as the Initial Presentation of Burkitt's Lymphoma/Leukemia: A Report of Two Cases and Review of the Literature.双侧颏部麻木综合征作为伯基特淋巴瘤/白血病的首发表现:两例报告并文献复习
Case Rep Hematol. 2016;2016:3791045. doi: 10.1155/2016/3791045. Epub 2016 Nov 1.
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Numb Chin Syndrome.麻木性颏部综合征
Curr Pain Headache Rep. 2015 Sep;19(9):44. doi: 10.1007/s11916-015-0515-y.
6
A pitfall of brain MRI in evaluation of numb chin syndrome: mandibular MRI should be included to localize lesions.脑部MRI评估麻木性颏部综合征的一个陷阱:应包括下颌MRI以定位病变。
J Neurol Sci. 2014 Oct 15;345(1-2):265-6. doi: 10.1016/j.jns.2014.07.029. Epub 2014 Jul 18.
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Mental nerve neuropathy following dental extraction.拔牙后颏神经神经病变
Pain Physician. 2014 May-Jun;17(3):E375-80.
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Neurological red flag: the numb chin.神经学警示信号:下巴麻木。
Pract Neurol. 2014 Aug;14(4):258-60. doi: 10.1136/practneurol-2013-000738. Epub 2013 Nov 22.
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Correlation between transcription factor Snail1 expression and prognosis in adenoid cystic carcinoma of salivary gland.涎腺腺样囊性癌中转录因子Snail1表达与预后的相关性
Oral Surg Oral Med Oral Pathol Oral Radiol Endod. 2010 Dec;110(6):764-9. doi: 10.1016/j.tripleo.2010.06.015. Epub 2010 Oct 16.
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Anticancer Res. 2010 May;30(5):1819-21.