Laczay P, Simon F, Móra Z, Lehel J
Dtsch Tierarztl Wochenschr. 1989 Oct;96(9):449-51.
The compatibility of Salinomycin, Narasin or Maduramycin with Tiamulin, Erythromycin, Tylosin, Kitasamycin, Flumequine, Sulfachlorpyrazine or Sulfaquinoxaline was tested in cockerels in three experiments. It was found that Salinomycin and Narasin are incompatible with Tiamulin, Erythromycin, Sulfachlorpyrazine and Sulfaquinoxaline. The effect of incompatibility was shown more markedly with the administration of Salinomycin than with Narasin. Maduramycin was also shown as incompatible with Tiamulin although this interaction was nowhere near as severe as in the case of Salinomycin or Narasin. It caused a significant weight gain depression without mortality. Because of the significant weight gain depression, however, the administration of Tiamulin in the presence of Maduramycin in feed will not be recommended. At the same time, Maduramycin proved to be fully compatible with Erythromycin, Sulfachlorpyrazine and Sulfaquinoxaline. All three anticoccidials tested showed total compatibility with Tylosin, Kitasamycin and Flumequine.
在三项实验中,对盐霉素、那拉菌素或马杜霉素与泰妙菌素、红霉素、泰乐菌素、吉他霉素、氟甲喹、磺胺氯吡嗪或磺胺喹恶啉的配伍性在公鸡中进行了测试。发现盐霉素和那拉菌素与泰妙菌素、红霉素、磺胺氯吡嗪和磺胺喹恶啉不相容。盐霉素给药时不相容的影响比那拉菌素更明显。马杜霉素也显示与泰妙菌素不相容,尽管这种相互作用远不如盐霉素或那拉菌素的情况严重。它导致显著的体重增加抑制但无死亡。然而,由于显著的体重增加抑制,不建议在饲料中马杜霉素存在的情况下使用泰妙菌素。同时,马杜霉素被证明与红霉素、磺胺氯吡嗪和磺胺喹恶啉完全相容。所测试的三种抗球虫药均显示与泰乐菌素、吉他霉素和氟甲喹完全相容。