Romero P, Barnett P G, Midtling J E
Department of Family Medicine, Natividad Medical Center, Salinas, California 93912.
Environ Res. 1989 Dec;50(2):256-61. doi: 10.1016/s0013-9351(89)80006-4.
Thirty-five workers became ill after they entered a cauliflower field contaminated with residues of three different insecticides, the organophosphates oxydemeton-methyl (Metasystox-R) and mevinphos (Phosdrin), and a carbamate, methomyl (Lannate). One crew member was pregnant with a 4-week-old fetus. At birth, the 3200-g female infant had multiple cardiac defects, bilateral optic nerve colobomas, microphthalmia of the left eye, cerebral and cerebellar atrophy, and facial anomalies. The cardiac defects included ventricular and atrial septal defects, stenosis of the pulmonary artery, and a patent ductus arteriosus. The child died at 14 days of age. There was no family history of birth defects, nor any maternal risk factor present, except that doxylamine (Bendectin) had been prescribed at 9 weeks fetal age. It is unlikely that doxylamine was responsible for the observed anomalies. Of the three chemicals involved, reproductive effects in test organisms have been observed only with oxydemeton-methyl. This case represents the first report of human malformations associated with prenatal exposure to this chemical. Further studies may be warranted to determine if a causal relationship exists.
35名工人进入一块被三种不同杀虫剂残留污染的花椰菜地后生病，这三种杀虫剂分别是有机磷酸酯类的氧化乐果（甲基乙拌磷）和速灭磷（磷君），以及氨基甲酸酯类的灭多威（万灵）。一名机组人员怀有一个4周大的胎儿。出生时，这个体重3200克的女婴有多种心脏缺陷、双侧视神经缺损、左眼小眼症、大脑和小脑萎缩以及面部畸形。心脏缺陷包括室间隔和房间隔缺损、肺动脉狭窄以及动脉导管未闭。这孩子在14日龄时死亡。除了在胎儿9周龄时曾开具过苯海拉明（敏克静）外，没有出生缺陷的家族病史，也不存在任何母体风险因素。苯海拉明不太可能是所观察到的异常情况的原因。在所涉及的三种化学物质中，仅在氧化乐果对试验生物中观察到了生殖影响。该病例是关于产前接触这种化学物质导致人类畸形的首例报告。可能需要进一步研究以确定是否存在因果关系。
