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碳水化合物限制饮食的训练和未训练大鼠的糖原代谢与运动后酮症

Glycogen metabolism and post-exercise ketosis in carbohydrate-restricted trained and untrained rats.

作者信息

Adams J H, Koeslag J H

机构信息

Department of Physiology, University of Cape Town Medical School, Observatory, South Africa.

出版信息

Q J Exp Physiol. 1989 Jan;74(1):27-34. doi: 10.1113/expphysiol.1989.sp003236.

DOI:10.1113/expphysiol.1989.sp003236
PMID:2717702
Abstract

Liver and muscle glycogen, and blood 3-hydroxybutyrate concentrations were studied during and for 2 h after treadmill running for 1 h, in 144 carbohydrate-starved trained and untrained rats. The resting liver glycogen concentration of the trained animals was 227 +/- 8 (mean +/- S.E.M.) mumol glucosyl units/g wet mass, compared with 162 +/- 12 mumol/g in the untrained animals. The muscle glycogen levels were 42 +/- 1 and 28 +/- 1 mumol/g respectively. Exercise reduced muscle and liver glycogen concentrations by approximately the same absolute amounts in both animal groups, leaving the trained rats with nearly 3 times as much residual glycogen as the untrained animals. There was very little resynthesis of muscle glycogen recovery, but the trained animals replenished approximately 43% of the liver glycogen used during exercise. The blood 3-hydroxybutyrate concentrations were negatively correlated with the simultaneous liver glycogen concentration of our experimental animals (r = -0.55; P less than 0.001). It is concluded that trained animals primarily owe their resistance to post-exercise ketosis to their large stores of glycogen.

摘要

在144只碳水化合物缺乏的训练有素和未经训练的大鼠中,研究了跑步机跑步1小时期间及之后2小时内肝脏和肌肉糖原以及血液中3-羟基丁酸酯的浓度。训练有素的动物静息时肝脏糖原浓度为227±8(平均值±标准误)微摩尔葡萄糖基单位/克湿质量,而未经训练的动物为162±12微摩尔/克。肌肉糖原水平分别为42±1和28±1微摩尔/克。运动使两组动物的肌肉和肝脏糖原浓度降低的绝对量大致相同,训练有素的大鼠剩余糖原几乎是未经训练动物的3倍。肌肉糖原恢复的再合成很少,但训练有素的动物补充了运动期间消耗的约43%的肝脏糖原。我们实验动物的血液3-羟基丁酸酯浓度与同时期的肝脏糖原浓度呈负相关(r = -0.55;P < 0.001)。结论是,训练有素的动物对运动后酮症的抵抗力主要归因于其大量的糖原储备。

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