Cayir Atilla, Turan Mehmet Ibrahim, Ozkan Ozalkan, Cayir Yasemin
J Pak Med Assoc. 2014 Nov;64(11):1274-7.
To investigate the relationship between Vitamin D deficiency and acute otitis media infection.
The randomised, single-blind, case-control study was conducted at the Paediatric Department of Ataturk University, Erzurum, Turkey, from January to April 2010. It comprised ambulatory children diagnosed with acute otitis media and healthy controls. The subjects were divided into groups according to their serum 25-hydroxy vitamin D levels. SPSS 18 was used for statistical analysis.
Of the 169 subjects in the study, 88(52%) were the cases and 81(48%) were controls. The mean age of the cases was 6.21±3.4 years, and 6.18±3.12 years for the controls (p<0.951). Serum 25-hydroxy vitamin D levels in the cases and controls were 20.6±10.2 ng/mL and 23.8±10.3 ng/mL (p<0.05). There was no statistically significant difference between the groups in terms of parathormone and calcium levels (p>0.05).
Serum 25-hydroxy vitamin D levels being significantly lower in children diagnosed with acute otitis media compared to the controls in two otherwise similar groups suggests that Vitamin D deficiency plays a role in otitis media infection.
探讨维生素D缺乏与急性中耳炎感染之间的关系。
2010年1月至4月，在土耳其埃尔祖鲁姆阿塔图尔克大学儿科进行了一项随机、单盲、病例对照研究。研究对象包括诊断为急性中耳炎的门诊儿童和健康对照者。根据血清25-羟维生素D水平将受试者分组。采用SPSS 18进行统计分析。
研究中的169名受试者中，88例（52%）为病例组，81例（48%）为对照组。病例组的平均年龄为6.21±3.4岁，对照组为6.18±3.12岁（p<0.951）。病例组和对照组的血清25-羟维生素D水平分别为20.6±10.2 ng/mL和23.8±10.3 ng/mL（p<0.05）。两组间甲状旁腺激素和钙水平无统计学显著差异（p>0.05）。
在两个其他方面相似的组中，诊断为急性中耳炎的儿童血清25-羟维生素D水平明显低于对照组，这表明维生素D缺乏在中耳炎感染中起作用。
