Umeadi Esther Ngozi, Echendu Sylvia Tochukwu, Ufoaroh Chinyelu Uchenna, Igwe Wilson Chukwuneke, Ezeudu Chijioke Elias, Anyabolu Ernest Ndukaife, Ebenebe Joy Chinelo, Egbuonu Ifeoma
Department of Paediatrics, Nnamdi Azikiwe University, Awka Nigeria.
Department of Paediatrics, Nnamdi Azikiwe University Teaching Hospital, Nnewi, Nigeria.
Niger Med J. 2022 Sep 12;63(3):204-212. doi: 10.60787/NMJ-63-3-134. eCollection 2022 May-Jun.
This study sought to evaluate the association between serum vitamin D levels and acute respiratory infection (ARI) in under-five children in Nnamdi Azikiwe University Teaching Hospital (NAUTH) in Nigeria.
This study was conducted in NAUTH, Nigeria, in 2017, in 250 children with ARI, classified into those with acute upper respiratory infection (AURI) and those with acute lower respiratory infection (ALRI). and 250 children without ARI, matched for age and gender. Sociodemographic data and serum vitamin D were obtained. The data were compared between the study and the control groups. The data were compared between those with AURI and those with ALRI.
The mean serum 25(OH)D of (52.2±25.6 ng/ml) in the study subjects was lower than the (57.0±23.9 ng/ml in the control group (t=2.20, p=0.03).The mean serum 25(OH)D levels in children with ALRI [39.8±23.8 ng/ml] was lower than in those with AURI [56.0±24.9ng/ml] (t= 14.83, p <0.001). In addition, the association between low levels of serum 25(OH)D and severity of ALRI was significant (x2 = 9.45, p = 0.002).
In under-five children, serum vitamin D levels were low, and these low levels were associated more with ALRIs than AURIs in this study.
本研究旨在评估尼日利亚纳姆迪·阿齐克韦大学教学医院（NAUTH）五岁以下儿童血清维生素D水平与急性呼吸道感染（ARI）之间的关联。
2017年在尼日利亚的NAUTH对250名患ARI的儿童进行了研究，这些儿童被分为患有急性上呼吸道感染（AURI）的儿童和患有急性下呼吸道感染（ALRI）的儿童，同时选取了250名无ARI的儿童作为对照，根据年龄和性别进行匹配。收集了社会人口统计学数据和血清维生素D数据。对研究组和对照组的数据进行了比较，也对患有AURI的儿童和患有ALRI的儿童的数据进行了比较。
研究对象的血清25(OH)D平均水平为(52.2±25.6 ng/ml)，低于对照组的(57.0±23.9 ng/ml)（t=2.20，p=0.03）。患有ALRI的儿童血清25(OH)D平均水平[39.8±23.8 ng/ml]低于患有AURI的儿童[56.0±24.9ng/ml]（t=14.83，p<0.001）。此外，血清25(OH)D水平低与ALRI严重程度之间的关联具有显著性（x2 = 9.45，p = 0.002）。
在五岁以下儿童中，血清维生素D水平较低，且在本研究中，这些低水平与ALRI的关联比与AURI的关联更大。
