Fraune Johanna, Alsheimer Manfred, Redolfi Josef, Brochier-Armanet Céline, Benavente Ricardo
Department of Cell and Developmental Biology, University of Würzburg, Würzburg, Germany.
Cytogenet Genome Res. 2014;144(4):299-305. doi: 10.1159/000381080. Epub 2015 Mar 28.
During the first meiotic prophase, chromosome synapsis is mediated by the synaptonemal complex (SC), an evolutionarily conserved meiosis-specific structure. In mammals, 7 SC protein components have been identified so far. Despite some controversy in the past, we have shown that SC proteins are ancient in metazoans and very likely formed an ancestral SC structure in the ancestor of metazoans. Protein components SYCP1, SYCP3, SYCE2, and TEX12 were identified in basal-branching metazoans, while other components (SYCE1 and SYCE3) are more recent elements. However, the evolutionary history of mammalian SYCP2 is not known. Here, we investigated this aspect with the aid of bioinformatic tools as well as with RNA and protein expression analysis. We conclude that SYCP2 belongs to the group of ancient SC proteins that was already present in the common ancestor of metazoans more than 500 million years ago.
在第一次减数分裂前期，染色体联会由联会复合体（SC）介导，这是一种在进化上保守的减数分裂特异性结构。在哺乳动物中，迄今已鉴定出7种SC蛋白成分。尽管过去存在一些争议，但我们已经表明，SC蛋白在后生动物中很古老，并且很可能在后生动物的祖先中形成了祖先SC结构。在基部分支的后生动物中鉴定出了蛋白成分SYCP1、SYCP3、SYCE2和TEX12，而其他成分（SYCE1和SYCE3）是较新的元素。然而，哺乳动物SYCP2的进化历史尚不清楚。在这里，我们借助生物信息学工具以及RNA和蛋白质表达分析对这一方面进行了研究。我们得出结论，SYCP2属于古老的SC蛋白群体，早在5亿多年前就已存在于后生动物的共同祖先中。
