Imai Yukiko, Olaya Ivan, Sakai Noriyoshi, Burgess Sean M
Department of Gene Function and Phenomics, National Institute of Genetics, Mishima, Japan.
Department of Molecular and Cellular Biology, University of California, Davis, Davis, CA, United States.
Front Cell Dev Biol. 2021 Oct 8;9:757445. doi: 10.3389/fcell.2021.757445. eCollection 2021.
Recent studies in zebrafish have revealed key features of meiotic chromosome dynamics, including clustering of telomeres in the bouquet configuration, biogenesis of chromosome axis structures, and the assembly and disassembly of the synaptonemal complex that aligns homologs end-to-end. The telomere bouquet stage is especially pronounced in zebrafish meiosis and sub-telomeric regions play key roles in mediating pairing and homologous recombination. In this review, we discuss the temporal progression of these events in meiosis prophase I and highlight the roles of proteins associated with meiotic chromosome architecture in homologous recombination. Finally, we discuss the interplay between meiotic mutants and gonadal sex differentiation and future research directions to study meiosis in living cells, including cell culture.
最近对斑马鱼的研究揭示了减数分裂染色体动力学的关键特征，包括端粒在花束构型中的聚集、染色体轴结构的生物发生，以及将同源染色体端对端对齐的联会复合体的组装和解聚。端粒花束阶段在斑马鱼减数分裂中尤为明显，亚端粒区域在介导配对和同源重组中起关键作用。在这篇综述中，我们讨论了减数分裂前期I中这些事件的时间进程，并强调了与减数分裂染色体结构相关的蛋白质在同源重组中的作用。最后，我们讨论了减数分裂突变体与性腺性别分化之间的相互作用，以及研究活细胞（包括细胞培养）中减数分裂的未来研究方向。
