Saji Hideo
Graduate School of Pharmaceutical Sciences, Kyoto University.
Yakugaku Zasshi. 2015;135(4):551-6. doi: 10.1248/yakushi.14-00227-2.
Radioisotopes emit radiation with various characteristics. These characteristics have been used for various applications of radioisotopes in clinical fields. For example, diagnostic nuclear medicine is a technique that uses gamma-emitted radionuclides with high permeability into the body and can visualize changes in physiological and biochemical processes throughout the distributed and interrelated systems of living tissues and organs. Therapeutic nuclear medicine is a technique that uses beta-emitted radionuclides with high radiation damage to the cell and can be used for internal radiation therapy. Therefore, a strategy in which the same ligand is labeled with beta-emitted or gamma-emitted radioisotopes, i.e., a theranostics approach, is useful because an extensive availability of diagnostics and therapeutics is possible. In this presentation, some examples of a theranostics approach for radiolabeled compounds will be reported, including the results of our recent research.
放射性同位素发射具有各种特性的辐射。这些特性已被用于放射性同位素在临床领域的各种应用。例如，诊断性核医学是一种利用发射γ射线的放射性核素的技术，这些核素对身体具有高渗透性，并且可以使整个活组织和器官的分布和相互关联系统中的生理和生化过程的变化可视化。治疗性核医学是一种利用发射β射线的放射性核素的技术，这些核素对细胞具有高辐射损伤，可用于内照射治疗。因此，用发射β射线或发射γ射线的放射性同位素标记相同配体的策略，即诊疗一体化方法，是有用的，因为这样可以广泛地进行诊断和治疗。在本报告中，将报告一些放射性标记化合物的诊疗一体化方法的实例，包括我们最近的研究结果。
