放射性核素激活纳米材料及其生物医学应用。
Radionuclide-Activated Nanomaterials and Their Biomedical Applications.
机构信息
Departments of Radiology, Biomedical Engineering, and Medical Physics, University of Wisconsin-Madison, Madison, Wisconsin, 53705, USA.
出版信息
Angew Chem Int Ed Engl. 2019 Sep 16;58(38):13232-13252. doi: 10.1002/anie.201900594. Epub 2019 Jul 8.
Abstract
Radio-nanomedicine, or the use of radiolabeled nanoparticles in nuclear medicine, has attracted much attention in the last few decades. Since the discovery of Cerenkov radiation and its employment in Cerenkov luminescence imaging, the combination of nanomaterials and Cerenkov radiation emitters has been revolutionizing the way nanomaterials are perceived in the field: from simple inert carriers of radioactivity to activatable nanomaterials for both diagnostic and therapeutic applications. Herein, we provide a comprehensive review on the types of nanomaterials that have been used to interact with Cerenkov radiation and the gamma and beta scintillation of radionuclides, as well as on their biological applications.
摘要
放射纳米医学，或核医学中放射性标记纳米粒子的应用，在过去几十年中引起了广泛关注。自切伦科夫辐射的发现及其在切伦科夫发光成像中的应用以来，纳米材料与切伦科夫辐射发射器的结合已经彻底改变了人们对该领域纳米材料的认识：从放射性的简单惰性载体到用于诊断和治疗应用的可激活纳米材料。本文综述了用于与切伦科夫辐射以及放射性核素的γ和β闪烁相互作用的纳米材料的类型，以及它们的生物学应用。
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