Indhavivadhana Suchada, Rattanasrithong Panwad
Gynecologic Endocrinology Unit, Division of Reproductive Medicine, Department of Obstetrics and Gynecology, Faculty of Medicine Siriraj Hospital, Mahidol University, 2 Prannok Rd, Bangkok Noi, Bangkok, 10700, Thailand.
Arch Gynecol Obstet. 2015 Nov;292(5):1127-33. doi: 10.1007/s00404-015-3698-x. Epub 2015 Apr 2.
To compare the bone mineral density (BMD) measured in the lumbar spine and femoral neck in peri- and post-menopausal Thai women with and without metabolic syndrome, and to determine which contributory factors associated with metabolic syndrome influence BMD.
427 peri- or post-menopausal Thai women were screened against the modified National Cholesterol Education Program Adult Treatment Panel III (NCEP ATP III) for Asian populations' criteria for metabolic syndrome. The BMD of those with and without metabolic syndrome was compared, and potential relationships between the factors associated with metabolic syndrome and BMD were sought.
There was no difference in lumbar spine or femoral neck BMD between the groups (p = 0.605 and 0.415, respectively), but women with central obesity (waist circumference ≥80 cm, p = 0.004 and >88 cm, p = 0.002), low serum high-density lipoprotein cholesterol (HDL-C) concentration (p = 0.011) and a greater number of contributory factors to metabolic syndrome (p = 0.007) had significantly higher BMD at the femoral neck.
A diagnosis of metabolic syndrome did not correlate with either lumbar spine or femoral neck BMD. However, higher femoral neck BMD was significantly associated with increased waist circumference, low serum HDL-C concentration and the number of contributory factors to metabolic syndrome.
比较患有和未患有代谢综合征的泰国围绝经期和绝经后女性腰椎和股骨颈的骨密度（BMD），并确定与代谢综合征相关的哪些促成因素会影响骨密度。
根据针对亚洲人群的改良美国国家胆固醇教育计划成人治疗小组第三次报告（NCEP ATP III）标准，对427名泰国围绝经期或绝经后女性进行代谢综合征筛查。比较患有和未患有代谢综合征者的骨密度，并探寻与代谢综合征相关的因素和骨密度之间的潜在关系。
两组之间腰椎或股骨颈骨密度无差异（分别为p = 0.605和0.415），但患有中心性肥胖（腰围≥80 cm，p = 0.004；> 88 cm，p = 0.002）、血清高密度脂蛋白胆固醇（HDL-C）浓度低（p = 0.011）以及代谢综合征促成因素数量较多（p = 0.007）的女性股骨颈骨密度显著更高。
代谢综合征的诊断与腰椎或股骨颈骨密度均无关联。然而，较高的股骨颈骨密度与腰围增加、血清HDL-C浓度低以及代谢综合征促成因素数量显著相关。
