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核心技术专利：CN118964589B侵权必究

核心技术专利：CN118964589B侵权必究

Foster P S, White M D, Denborough M A

Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT.

Int J Biochem. 1989;21(10):1119-26. doi: 10.1016/0020-711x(89)90053-0.

The sarcoplasmic reticulum (SR) from malignant hyperpyrexia susceptible (MHS) and control porcine skeletal muscle was separated into vesicular fractions enriched in the membrane elements of the terminal cisternae and longitudinal tubules. 2. The two membrane preparations were highly purified and had distinctive features which were associated with their origins in the SR membraneous network. 3. Calsequestrin and calcium were enriched in the terminal cisternae fraction (HSR), in comparison to longitudinal tubule preparations (LSR). 4. The HSR membrane also had a greater total capacity to store Ca2+ and Ca2+ release was more rapid than from LSR preparations. 5. No distinction could be made between the membrane morphology, Ca2+ -fluxes or Ca2+ -dependent ATPase activities, associated with these functionally distinct regions of MHS and control preparations.

从恶性高热易感（MHS）猪和对照猪骨骼肌中分离出肌浆网（SR），并将其分成富含终末池和纵管膜成分的囊泡部分。2. 两种膜制剂经过高度纯化，具有与其在SR膜网络中的起源相关的独特特征。3. 与纵管制剂（LSR）相比，终末池部分（HSR）中集钙蛋白和钙含量丰富。4. HSR膜储存Ca2+的总能力也更强，且Ca2+释放比LSR制剂更快。5. 在MHS和对照制剂这些功能不同的区域相关的膜形态、Ca2+通量或Ca2+依赖性ATP酶活性之间无法做出区分。

Foster P S, White M D, Denborough M A

Division of Biochemistry and Molecular Biology, John Curtin School of Medical Research, Australian National University, Canberra, ACT.

Int J Biochem. 1989;21(10):1119-26. doi: 10.1016/0020-711x(89)90053-0.

The sarcoplasmic reticulum (SR) from malignant hyperpyrexia susceptible (MHS) and control porcine skeletal muscle was separated into vesicular fractions enriched in the membrane elements of the terminal cisternae and longitudinal tubules. 2. The two membrane preparations were highly purified and had distinctive features which were associated with their origins in the SR membraneous network. 3. Calsequestrin and calcium were enriched in the terminal cisternae fraction (HSR), in comparison to longitudinal tubule preparations (LSR). 4. The HSR membrane also had a greater total capacity to store Ca2+ and Ca2+ release was more rapid than from LSR preparations. 5. No distinction could be made between the membrane morphology, Ca2+ -fluxes or Ca2+ -dependent ATPase activities, associated with these functionally distinct regions of MHS and control preparations.

从恶性高热易感（MHS）猪和对照猪骨骼肌中分离出肌浆网（SR），并将其分成富含终末池和纵管膜成分的囊泡部分。2. 两种膜制剂经过高度纯化，具有与其在SR膜网络中的起源相关的独特特征。3. 与纵管制剂（LSR）相比，终末池部分（HSR）中集钙蛋白和钙含量丰富。4. HSR膜储存Ca2+的总能力也更强，且Ca2+释放比LSR制剂更快。5. 在MHS和对照制剂这些功能不同的区域相关的膜形态、Ca2+通量或Ca2+依赖性ATP酶活性之间无法做出区分。