丹曲林对猪恶性高热时骨骼肌肌浆网功能的影响。
The effect of dantrolene on skeletal-muscle sarcoplasmic-reticulum function in malignant hyperpyrexia in pigs.
作者信息
White M D, Collins J G, Denborough M A
出版信息
Biochem J. 1983 May 15;212(2):399-405. doi: 10.1042/bj2120399.
Abstract
The effect of the muscle relaxant dantrolene on isolated sarcoplasmic reticulum was studied in control and malignant-hyperpyrexia-susceptible Landrace pigs. The membranes prepared from both sources showed similar Ca2+-dependent ATPase activities, had comparable phospholipid/protein ratios, and their sodium dodecyl sulphate/polyacrylamide-gel patterns were indistinguishable. Membranes from both sources appeared to bind similar amounts of dantrolene. The drug did not stimulate Ca2+-dependent ATPase activity in preparations from either source. The rates of Ca2+ exchange and Ca2+ efflux appeared to be similar in sarcoplasmic reticulum of control and malignant-hyperpyrexia-susceptible pigs. Dantrolene did not affect either the rates or the amount of Ca2+ lost from the vesicles. These results suggest that dantrolene does not directly affect the movement of Ca2+ across the sarcoplasmic-reticulum membrane.
摘要
在对照和易患恶性高热的长白猪中研究了肌肉松弛剂丹曲林对分离的肌浆网的作用。从这两种来源制备的膜显示出相似的钙依赖性ATP酶活性，具有相当的磷脂/蛋白质比率，并且它们的十二烷基硫酸钠/聚丙烯酰胺凝胶图谱无法区分。来自这两种来源的膜似乎结合了相似量的丹曲林。该药物在来自任何一种来源的制剂中均未刺激钙依赖性ATP酶活性。对照猪和易患恶性高热的猪的肌浆网中钙交换和钙流出的速率似乎相似。丹曲林既不影响从囊泡中丢失的钙的速率，也不影响其数量。这些结果表明，丹曲林不会直接影响钙跨肌浆网膜的移动。
相似文献
1
The effect of dantrolene on skeletal-muscle sarcoplasmic-reticulum function in malignant hyperpyrexia in pigs.丹曲林对猪恶性高热时骨骼肌肌浆网功能的影响。
Biochem J. 1983 May 15;212(2):399-405. doi: 10.1042/bj2120399.
2
Dantrolene and calcium uptake by the sarcoplasmic reticulum of malignant hyperpyrexia-susceptible pigs.
Gen Pharmacol. 1984;15(2):129-32. doi: 10.1016/0306-3623(84)90094-6.
3
Enhanced Ca2+-induced calcium release by isolated sarcoplasmic reticulum vesicles from malignant hyperthermia susceptible pig muscle.恶性高热易感猪肌肉中分离出的肌浆网囊泡增强了钙诱导的钙释放。
Biochim Biophys Acta. 1986 Nov 17;862(2):318-28. doi: 10.1016/0005-2736(86)90234-8.
4
The effect of calcium channel antagonists and BAY K 8644 on calcium fluxes of malignant hyperpyrexia-susceptible muscle.钙通道拮抗剂和BAY K 8644对恶性高热易感肌肉钙通量的影响。
Int J Biochem. 1993 Apr;25(4):495-504. doi: 10.1016/0020-711x(93)90656-y.
5
Effects of halothane, caffeine, dantrolene and tetracaine on the calcium permeability of skeletal sarcoplasmic reticulum of malignant hyperthermic pigs.氟烷、咖啡因、丹曲林和丁卡因对恶性高热猪骨骼肌肌浆网钙通透性的影响。
Biochim Biophys Acta. 1987 Feb 26;897(2):261-8. doi: 10.1016/0005-2736(87)90422-6.
6
Uptake and release of calcium ions by heavy sarcoplasmic reticulum fraction of normal and malignant hyperthermia-susceptible human skeletal muscle.正常及恶性高热易感型人类骨骼肌重肌质网部分对钙离子的摄取与释放
Int J Biochem. 1990;22(4):329-33. doi: 10.1016/0020-711x(90)90134-o.
7
The effect of azumolene on hypercontractility and sarcoplasmic reticulum Ca(2+)-dependent ATPase activity of malignant hyperpyrexia-susceptible porcine skeletal muscle.
Clin Exp Pharmacol Physiol. 1991 Jul;18(7):489-95. doi: 10.1111/j.1440-1681.1991.tb01482.x.
8
Dantrolene does not block calcium pulse-induced calcium release from a putative calcium channel in sarcoplasmic reticulum from malignant hyperthermia and normal pig muscle.
FEBS Lett. 1984 Feb 13;167(1):123-30. doi: 10.1016/0014-5793(84)80845-5.
9
Calcium-induced Ca2+ release from sarcoplasmic reticulum of pigs susceptible to malignant hyperthermia. The effects of halothane and dantrolene.钙诱导猪恶性高热易感肌浆网释放钙离子。氟烷和丹曲林的作用。
FEBS Lett. 1983 Sep 5;161(1):103-7. doi: 10.1016/0014-5793(83)80739-x.
10
The effects of calmodulin antagonist drugs on isolated sarcoplasmic reticulum from malignant hyperpyrexia susceptible swine.钙调蛋白拮抗剂药物对恶性高热易感猪的离体肌浆网的作用。
Int J Biochem. 1987;19(9):819-26. doi: 10.1016/0020-711x(87)90240-0.
引用本文的文献
1
Ca2+ signaling in the transformation of promastigotes to axenic amastigotes of Leishmania donovani.杜氏利什曼原虫前鞭毛体向无细胞培养无鞭毛体转化过程中的钙离子信号传导
Mol Cell Biochem. 2001 Aug;224(1-2):39-44. doi: 10.1023/a:1011965109446.
2
Malignant hyperthermia: molecular defects in membrane permeability.恶性高热：膜通透性的分子缺陷
Experientia. 1985 May 15;41(5):656-61. doi: 10.1007/BF02007707.
3
Dantrolene. A review of its pharmacodynamic and pharmacokinetic properties and therapeutic use in malignant hyperthermia, the neuroleptic malignant syndrome and an update of its use in muscle spasticity.丹曲林。对其药效学、药代动力学特性以及在恶性高热、抗精神病药物恶性综合征中的治疗用途的综述，并更新其在肌肉痉挛中的应用。
Drugs. 1986 Aug;32(2):130-68. doi: 10.2165/00003495-198632020-00003.
4
Skeletal muscle excitation-contraction coupling. I. Transverse tubule control of peeled fiber Ca2+-induced Ca2+ release in normal and malignant hyperthermic muscles.骨骼肌兴奋-收缩偶联。I. 正常和恶性高热肌肉中横管对脱膜纤维钙诱导钙释放的控制。
Pflugers Arch. 1989 May;414(1):15-23. doi: 10.1007/BF00585621.
5
Pharmacology of calcium release from sarcoplasmic reticulum.肌浆网钙释放的药理学
J Bioenerg Biomembr. 1989 Apr;21(2):295-320. doi: 10.1007/BF00812074.
本文引用的文献
1
2
Binding of dantrolene sodium to muscle intracellular membranes.丹曲林钠与肌肉细胞内膜的结合。
FEBS Lett. 1980 Aug 11;117(1):37-8. doi: 10.1016/0014-5793(80)80908-2.
3
Temperature dependence of muscle function in malignant hyperpyrexia-susceptible swine.
Br J Anaesth. 1981 Nov;53(11):1217-22. doi: 10.1093/bja/53.11.1217.
4
Malignant hyperthermia.恶性高热
Anesthesiology. 1980 Nov;53(5):395-423. doi: 10.1097/00000542-198011000-00007.
5
Phosphorylation of heavy sarcoplasmic reticulum vesicles: identification and characterization of three phosphorylated proteins.重肌质网小泡的磷酸化作用：三种磷酸化蛋白的鉴定与表征
J Membr Biol. 1980 Oct 31;56(3):241-8. doi: 10.1007/BF01869479.
6
Further characterization of light and heavy sarcoplasmic reticulum vesicles. Identification of the 'sarcoplasmic reticulum feet' associated with heavy sarcoplasmic reticulum vesicles.肌浆网轻、重囊泡的进一步特征描述。与重肌浆网囊泡相关的“肌浆网足”的鉴定。
Biochim Biophys Acta. 1980 Oct 16;602(1):97-116. doi: 10.1016/0005-2736(80)90293-x.
7
A new and convenient colorimetric determination of inorganic orthophosphate and its application to the assay of inorganic pyrophosphatase.一种新型便捷的无机正磷酸盐比色测定法及其在无机焦磷酸酶测定中的应用。
Anal Biochem. 1981 May 15;113(2):313-7. doi: 10.1016/0003-2697(81)90082-8.
8
Cleavage of structural proteins during the assembly of the head of bacteriophage T4.在噬菌体T4头部组装过程中结构蛋白的切割
Nature. 1970 Aug 15;227(5259):680-5. doi: 10.1038/227680a0.
9
Dantrolene, a direct acting skeletal muscle relaxant.丹曲林，一种直接作用的骨骼肌松弛剂。
J Pharm Sci. 1973 Jun;62(6):948-51. doi: 10.1002/jps.2600620619.
10
Site of action of dantrolene in frog sartorius muscle.丹曲林在青蛙缝匠肌中的作用部位。
J Pharmacol Exp Ther. 1974 Apr;189(1):202-12.
Zotero 插件