钙调蛋白拮抗剂药物对恶性高热易感猪的离体肌浆网的作用。

The effects of calmodulin antagonist drugs on isolated sarcoplasmic reticulum from malignant hyperpyrexia susceptible swine.

Collins S P, White M D, Denborough M A

Department of Medicine and Clinical Science, John Curtin School of Medical Research, Australian National University, Canberra.

Int J Biochem. 1987;19(9):819-26. doi: 10.1016/0020-711x(87)90240-0.

Abstract

Because calcium antagonist drugs increase contracture in both control and malignant hyperpyrexia susceptible (MHS) skeletal muscle, the effect of these drugs on the sarcoplasmic reticulum (SR) was investigated. 2. The calmodulin antagonist drugs inhibited the Ca2+ dependent ATPase activity and the ATP-dependent Ca2+ uptake, and accelerated the efflux of Ca2+ from isolated SR preparations from both control and MHS skeletal muscle. These effects of calmodulin antagonist drugs on SR Ca2+ transport functions were consistent with their in vitro pharmacological effects on control and MHS muscle.

摘要

由于钙拮抗剂药物会增加对照和恶性高热易感（MHS）骨骼肌的挛缩，因此研究了这些药物对肌浆网（SR）的作用。2. 钙调蛋白拮抗剂药物抑制了Ca2+依赖性ATP酶活性和ATP依赖性Ca2+摄取，并加速了对照和MHS骨骼肌分离的SR制剂中Ca2+的外流。钙调蛋白拮抗剂药物对SR Ca2+转运功能的这些作用与其对对照和MHS肌肉的体外药理作用一致。