女性饮酒与银屑病关节炎发病风险
Alcohol intake and risk of incident psoriatic arthritis in women.
作者信息
Wu Shaowei, Cho Eunyoung, Li Wen-Qing, Han Jiali, Qureshi Abrar A
机构信息
From the Department of Dermatology, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School, Boston, Massachusetts; Department of Dermatology, the Warren Alpert Medical School of Brown University, Rhode Island; Department of Epidemiology, Richard M. Fairbanks School of Public Health, the Melvin and Bren Simon Cancer Center, and the Department of Dermatology, School of Medicine, Indiana University, Indianapolis, Indiana, USA.S. Wu, PhD, Department of Dermatology, Brigham and Women's Hospital and Harvard Medical School, and Department of Dermatology, The Warren Alpert Medical School of Brown University; E. Cho, ScD, Department of Dermatology, The Warren Alpert Medical School of Brown University, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School; W.Q. Li, PhD, Department of Dermatology, The Warren Alpert Medical School of Brown University; J. Han, PhD, Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital and Harvard Medical School, and the Department of Epidemiology, Richard M. Fairbanks School of Public Health, Melvin and Bren Simon Cancer Center, and the Department of Dermatology, School of Medicine, Indiana University; A.A. Qureshi, MD, MPH, Department of Dermatology, The Warren Alpert Medical School of Brown University, and the Channing Division of Network Medicine, Department of Medicine, Brigham and Women's Hospital, and Harvard Medical School.
出版信息
J Rheumatol. 2015 May;42(5):835-40. doi: 10.3899/jrheum.140808. Epub 2015 Apr 1.
OBJECTIVE
Alcohol intake has been associated with an increased risk of psoriasis. However, the association between alcohol intake and risk of psoriatic arthritis (PsA) has been unclear. We evaluated the association between alcohol intake and risk of incident PsA in a large cohort of US women.
METHODS
Our present study included a total of 82,672 US women who provided repeated data on alcohol intake over the followup period (1991-2005). Self-reported PsA was validated using the Psoriatic Arthritis Screening and Evaluation (PASE) questionnaire. Cox proportional hazards models were used to estimate the age-adjusted and multivariate-adjusted HR and 95% CI for the PsA in association with alcohol intake.
RESULTS
We documented 141 incident PsA cases during 14 years (1,137,763 person-yrs) of followup. Compared to non-drinkers, the multivariate HR for PsA were 0.70 (95% CI 0.48-1.01) for 0.1-14.9 g/day, 1.43 (95% CI 0.67-3.08) for 15.0-29.9 g/day, and 4.45 (95% CI 2.07-9.59) for ≥ 30.0 g/day of cumulative average alcohol intake. Risk estimates were generally consistent when using updated alcohol intake and baseline alcohol intake in 1991 as the exposures, and when the analysis was restricted to those who developed psoriasis during the followup.
CONCLUSION
Excessive alcohol intake was associated with an increased risk of incident PsA in a cohort of US women.
目的
酒精摄入与银屑病风险增加有关。然而，酒精摄入与银屑病关节炎（PsA）风险之间的关联尚不清楚。我们评估了美国一大群女性中酒精摄入与新发PsA风险之间的关联。
方法
我们目前的研究共纳入了82672名美国女性，她们在随访期间（1991 - 2005年）提供了关于酒精摄入的重复数据。使用银屑病关节炎筛查和评估（PASE）问卷对自我报告的PsA进行验证。采用Cox比例风险模型来估计与酒精摄入相关的PsA的年龄调整和多变量调整后的HR及95%CI。
结果
在14年（1137763人年）的随访期间，我们记录了141例新发PsA病例。与不饮酒者相比，累积平均酒精摄入量为0.1 - 14.9克/天的PsA多变量HR为0.70（95%CI 0.48 - 1.01），15.0 - 29.9克/天的为1.43（95%CI 0.67 - 3.08），≥30.0克/天的为4.45（95%CI 2.07 - 9.59）。当使用更新的酒精摄入量和1991年的基线酒精摄入量作为暴露因素时，以及当分析仅限于随访期间发生银屑病的人群时，风险估计总体上是一致的。
结论
在美国女性队列中，过量饮酒与新发PsA风险增加有关。
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