Mahajan Vikram K, Dhattarwal Niharika, Chauhan Pushpinder S, Mehta Karaninder S, Sharma Reena, Sharma Anuj, Singh Vijay K, Sharma Jyotshna, Hooda Sheenam
Department of Dermatology, Venereology, and Leprosy, Dr. Rajendra Prasad Govt. Medical College, (Tanda), Himachal Pradesh, India.
Indian Dermatol Online J. 2020 Sep 28;12(1):128-133. doi: 10.4103/idoj.IDOJ_226_20. eCollection 2021 Jan-Feb.
Association between alcohol consumption, alcohol use disorder, and clinical features of psoriasis patients has not been adequately studied in the Indian context.
To study the frequency of alcohol consumption, alcohol use disorder, and its association with age, gender, duration, and severity of psoriasis.
One hundred and forty-six (M: F 6.3:1) patients completed the Alcohol Use Disorder Identification Test (AUDIT) questionnaire by World Health Organization (WHO). Excessive drinkers, occasional drinkers, and abstainers were defined. AUDIT provided a measure of alcohol consumption, its dependence, and its impact on daily life. The severity of psoriasis was graded as mild, moderate, and severe.
Seventy-four (50.7%) patients were aged ≤40 years and 51.4% of patients had the disease for <5 years. Psoriasis was mild in 48.6% and moderate to severe in 51.4% of patients, respectively. Only males (32.9%) were consuming alcohol in varying amounts; 19.9% were occasional drinkers (AUDIT score <8). Other 67.1% of patients completely abstained from alcohol consumption (AUDIT score 0). The remaining 13% were regular drinkers (AUDIT score >8) and had more severe psoriasis compared to patients having AUDIT score <8 ( < 0.05). A high level of alcohol use disorder and alcohol dependence was present in one patient each.
Few patients, particularly females may not have disclosed their alcohol consumption due to fear of stigmatization. Small number of patients, hospital-based cross-sectional study design, and no follow-up for clinical improvement after cessation of alcohol are other limitations.
Alcohol consumption was associated with alcohol use disorder in 32.9% of patients (AUDIT score >8) and significantly severe psoriasis compared to 67.1% abstainers. Whether increased alcohol consumption is a consequence or a risk factor for chronicity of psoriasis needs large linear studies for confirmation.
在印度背景下，饮酒、酒精使用障碍与银屑病患者临床特征之间的关联尚未得到充分研究。
研究饮酒频率、酒精使用障碍及其与银屑病患者年龄、性别、病程和严重程度的关联。
146例患者（男:女为6.3:1）完成了世界卫生组织（WHO）的酒精使用障碍识别测试（AUDIT）问卷。定义了过度饮酒者、偶尔饮酒者和戒酒者。AUDIT提供了饮酒量、对酒精的依赖程度及其对日常生活影响的衡量指标。银屑病严重程度分为轻度、中度和重度。
74例（50.7%）患者年龄≤40岁，51.4%的患者病程<5年。48.6%的患者银屑病为轻度，51.4%的患者为中度至重度。只有男性（32.9%）有不同程度的饮酒；19.9%为偶尔饮酒者（AUDIT评分<8）。其他67.1%的患者完全戒酒（AUDIT评分0）。其余13%为经常饮酒者（AUDIT评分>8），与AUDIT评分<8的患者相比，银屑病更严重（<0.05）。各有1例患者存在高水平的酒精使用障碍和酒精依赖。
少数患者，尤其是女性，可能因担心被污名化而未披露饮酒情况。患者数量少、基于医院的横断面研究设计以及戒酒后未对临床改善情况进行随访是其他局限性。
与67.1%的戒酒者相比，32.9%的患者（AUDIT评分>8）饮酒与酒精使用障碍相关，且银屑病明显更严重。饮酒增加是银屑病慢性化的结果还是危险因素，需要大型队列研究来证实。
