Long Zi-Wen, Zhou Meng-Long, Fu Jing-Wei, Chu Xian-Qun, Wang Ya-Nong
Zi-Wen Long, Meng-Long Zhou, Ya-Nong Wang, Department of Gastric Cancer and Soft-tissue Sarcoma Surgery, Fudan University Shanghai Cancer Center, Shanghai 200032, China.
World J Gastroenterol. 2015 Mar 28;21(12):3694-705. doi: 10.3748/wjg.v21.i12.3694.
To construct a meta-analysis in order to examine the relationship between cadherin-17 (CDH17) and gastric cancer (GC).
Related articles were selected by searching the following English or Chinese electronic databases: CINAHL, MEDLINE, Science Citation Index, the Chinese Journal Full-Text, and the Weipu Journal. Newcastle-Ottawa Scale (NOS) criteria were used to ensure consistency in reviewing and reporting results. Statistical analyses were conducted with Version 12.0 STATA statistical software.
Ultimately, 11 articles, with a total of 2,120 GC patients, were found to be eligible for study inclusion. In comparisons of GC patients by TNM stage (III-IV vs I-II: OR = 2.35, 95%CI: 1.15-4.825, P = 0.019), histologic grade (3-4 vs 1-2: OR = 3.48, 95%CI: 1.36-8.92, P = 0.009), invasion grade (T3-4 vs T1-2: OR = 2.86; 95%CI: 1.69-4.83; P = 0.000), and lymph node metastasis (positive vs negative: OR = 2.64; 95%CI: 1.33-5.27; P = 0.006), it was found that CDH17 showed more positive expressions in each of the more severe cases. Country-stratified analyses from all four experimental subgroups showed that high CDH17 expression levels may be related to GC among Chinese and Korean populations (all P < 0.05), with the exception of the invasion grade T3-4 vs T1-2 comparison, where the relation only held among the Chinese population (OR = 2.86, 95%CI: 1.69-4.83, P = 0.000).
Collectively, the data reflects the capacity of CDH17 in tumor proliferation and metastasis among GC patients.
构建一项荟萃分析，以研究钙黏蛋白-17（CDH17）与胃癌（GC）之间的关系。
通过检索以下英文或中文电子数据库来选择相关文章：CINAHL、MEDLINE、科学引文索引、中国期刊全文数据库和维普期刊。采用纽卡斯尔-渥太华量表（NOS）标准来确保结果审查和报告的一致性。使用STATA 12.0统计软件进行统计分析。
最终，共发现11篇文章，涉及2120例GC患者，符合纳入研究标准。在按TNM分期（III-IV期与I-II期比较：OR = 2.35，95%CI：1.15 - 4.825，P = 0.019）、组织学分级（3 - 4级与1 - 2级比较：OR = 3.48，95%CI：1.36 - 8.92，P = 0.009）、浸润分级（T3 - 4期与T1 - 2期比较：OR = 2.86；95%CI：1.69 - 4.83；P = 0.000）以及淋巴结转移（阳性与阴性比较：OR = 2.64；95%CI：1.33 - 5.27；P = 0.006）对GC患者进行比较时，发现CDH17在每种更严重的病例中均表现出更多的阳性表达。来自所有四个实验亚组的国家分层分析表明，在中国和韩国人群中，CDH17高表达水平可能与GC有关（所有P < 0.05），浸润分级T3 - 4期与T1 - 2期比较除外，该关系仅在中国人群中成立（OR = 2.86，95%CI：¹.69¬ - 4.83，P = 0.000）。
总体而言，数据反映了CDH17在GC患者肿瘤增殖和转移中的作用。
