Mouse Cancer Genetics Program, National Cancer Institute, Frederick, MD 21702, USA.
Cancer Lett. 2013 Sep 10;338(1):110-9. doi: 10.1016/j.canlet.2013.03.035. Epub 2013 Apr 10.
Gastric cancer remains one of the leading causes of global cancer mortality. Multipotent gastric stem cells have been identified in both mouse and human stomachs, and they play an essential role in the self-renewal and homeostasis of gastric mucosa. There are several environmental and genetic factors known to promote gastric cancer. In recent years, numerous in vitro and in vivo studies suggest that gastric cancer may originate from normal stem cells or bone marrow-derived mesenchymal cells, and that gastric tumors contain cancer stem cells. Cancer stem cells are believed to share a common microenvironment with normal niche, which play an important role in gastric cancer and tumor growth. This mini-review presents a brief overview of the recent developments in gastric cancer stem cell research. The knowledge gained by studying cancer stem cells in gastric mucosa will support the development of novel therapeutic strategies for gastric cancer.
胃癌仍然是全球癌症死亡的主要原因之一。在人和鼠的胃中均已鉴定出多能胃干细胞,它们在胃黏膜的自我更新和稳态中发挥着重要作用。已知有几个环境和遗传因素可促进胃癌的发生。近年来,许多体外和体内研究表明,胃癌可能起源于正常干细胞或骨髓来源的间质细胞,并且胃肿瘤中含有癌症干细胞。癌症干细胞被认为与正常龛位具有共同的微环境,在胃癌和肿瘤生长中起着重要作用。这篇简要综述介绍了胃癌干细胞研究的最新进展。通过研究胃黏膜中的癌症干细胞获得的知识将支持开发治疗胃癌的新策略。