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Krüppel 样因子 4 诱导 SK-BR-3 乳腺癌细胞凋亡并抑制肿瘤发生进展。

Krüppel-like factor 4 induces apoptosis and inhibits tumorigenic progression in SK-BR-3 breast cancer cells.

机构信息

Department of Oncology, Affiliated Hospital of Hebei University, Baoding 071000, China.

Central Laboratory, Affiliated Hospital of Hebei University, Baoding 071000, China.

出版信息

FEBS Open Bio. 2015 Mar 2;5:147-54. doi: 10.1016/j.fob.2015.02.003. eCollection 2015.

DOI:10.1016/j.fob.2015.02.003
PMID:25834779
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC4359971/
Abstract

Krüppel-like factor 4 (KLF4) functions as either a tumor suppressor or an oncogene in different tissues by regulating the expression of various genes. The aim of this study was to reveal the functions of KLF4 in regulating breast cancer apoptosis, proliferation, and tumorigenic progression. KLF4 expression levels in breast cancer tissues and breast cancer cell lines were found to be much lower than those in nontumorous tissues and a nontransformed mammary epithelial cell line. KLF4 was upregulated in the tumor necrosis factor-α-induced SK-BR-3 breast cancer cell apoptotic process. Overexpression of KLF4 promoted SK-BR-3 breast cancer cell apoptosis and suppressed SK-BR-3 cell tumorigenicity in vivo.

摘要

Krüppel 样因子 4（KLF4）通过调节各种基因的表达，在不同组织中发挥肿瘤抑制因子或癌基因的作用。本研究旨在揭示 KLF4 在调节乳腺癌细胞凋亡、增殖和致瘤性进展中的作用。研究发现，乳腺癌组织和乳腺癌细胞系中的 KLF4 表达水平明显低于非肿瘤组织和未转化的乳腺上皮细胞系。肿瘤坏死因子-α诱导的 SK-BR-3 乳腺癌细胞凋亡过程中 KLF4 的表达上调。过表达 KLF4 可促进 SK-BR-3 乳腺癌细胞凋亡，并抑制体内 SK-BR-3 细胞的致瘤性。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e9/4359971/15b6fb13350b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e9/4359971/d549b342124d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e9/4359971/e48b0190360e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e9/4359971/2eaf5f54d01f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e9/4359971/15b6fb13350b/gr4.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e9/4359971/d549b342124d/gr1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e9/4359971/e48b0190360e/gr2.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e9/4359971/2eaf5f54d01f/gr3.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/b7e9/4359971/15b6fb13350b/gr4.jpg

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