Perri Paolo, Zauli Giorgio, Gonelli Arianna, Milani Daniela, Celeghini Claudio, Lamberti Giuseppe, Secchiero Paola
Department of Biomedical and Specialist Surgical Sciences, University of Ferrara, 44121 Ferrara, Italy.
Institute for Maternal and Child Health-IRCCS "Burlo Garofolo", 34137 Trieste, Italy.
Biomed Res Int. 2015;2015:424019. doi: 10.1155/2015/424019. Epub 2015 Mar 5.
TNF-related apoptosis inducing ligand (TRAIL) is an intensively studied cytokine, in particular for its anticancer activity. The discovery that conjunctival sac fluid contains extremely high levels of soluble TRAIL as compared to other body fluids suggested important implications in the context of the immunological surveillance of the eye, in particular of the anterior surface. In this review, we discuss the potential physiopathologic and therapeutic role of the TRAIL/TRAIL receptor system in a variety of ocular cancers. Moreover, since an increasing amount of data has indicated the important biological activities of the TRAIL/TRAIL receptor systems also in a completely different pathologic context such as diabetes mellitus, in the second part of this review we summarize the currently available data on the involvement of TRAIL in the ocular complications of diabetes mellitus as modulator of the inflammatory and angiogenic response in the eye.
肿瘤坏死因子相关凋亡诱导配体（TRAIL）是一种被深入研究的细胞因子，特别是因其抗癌活性。与其他体液相比，结膜囊液中含有极高水平的可溶性TRAIL这一发现提示了其在眼部免疫监视，尤其是眼前表面免疫监视中的重要意义。在本综述中，我们讨论了TRAIL/TRAIL受体系统在多种眼部癌症中的潜在生理病理和治疗作用。此外，由于越来越多的数据表明TRAIL/TRAIL受体系统在诸如糖尿病等完全不同的病理背景下也具有重要的生物学活性，在本综述的第二部分，我们总结了目前关于TRAIL作为眼部炎症和血管生成反应调节剂参与糖尿病眼部并发症的现有数据。
