Parkinson John S, Hazelbauer Gerald L, Falke Joseph J
Department of Biology, University of Utah, 257 South 1400 East, Salt Lake City, UT 84112, USA.
Department of Biochemistry, University of Missouri Columbia, Columbia, MO 65211, USA.
Trends Microbiol. 2015 May;23(5):257-66. doi: 10.1016/j.tim.2015.03.003. Epub 2015 Mar 30.
Motile Escherichia coli cells track gradients of attractant and repellent chemicals in their environment with transmembrane chemoreceptor proteins. These receptors operate in cooperative arrays to produce large changes in the activity of a signaling kinase, CheA, in response to small changes in chemoeffector concentration. Recent research has provided a much deeper understanding of the structure and function of core receptor signaling complexes and the architecture of higher-order receptor arrays, which, in turn, has led to new insights into the molecular signaling mechanisms of chemoreceptor networks. Current evidence supports a new view of receptor signaling in which stimulus information travels within receptor molecules through shifts in the dynamic properties of adjoining structural elements rather than through a few discrete conformational states.
运动性大肠杆菌细胞通过跨膜化学感受器蛋白追踪其环境中引诱剂和驱避剂化学物质的梯度。这些受体以协同阵列的形式运作，以响应化学效应物浓度的微小变化，在信号激酶CheA的活性上产生巨大变化。最近的研究对核心受体信号复合物的结构和功能以及高阶受体阵列的结构有了更深入的理解，这反过来又为化学感受器网络的分子信号传导机制带来了新的见解。目前的证据支持一种新的受体信号传导观点，即刺激信息在受体分子内通过相邻结构元件动态特性的变化传播，而不是通过少数离散的构象状态。
