De Angelis Maria, Francavilla Ruggiero, Piccolo Maria, De Giacomo Andrea, Gobbetti Marco
a Department of Soil; Plant and Food Sciences; University of Bari Aldo Moro ; Bari , Italy.
Gut Microbes. 2015;6(3):207-13. doi: 10.1080/19490976.2015.1035855.
Through extensive microbial-mammalian co-metabolism, the intestinal microbiota have evolved to exert a marked influence on health and disease via gut-brain-microbiota interactions. In this addendum, we summarize the findings of our recent study on the fecal microbiota and metabolomes of children with pervasive developmental disorder-not otherwise specified (PDD-NOS) or autism (AD) compared with healthy children (HC). Children with PDD-NOS or AD have altered fecal microbiota and metabolomes (including neurotransmitter molecules). We hypothesize that the degree of microbial alteration correlates with the severity of the disease since fecal microbiota and metabolomes alterations were higher in children with PDD-NOS and, especially, AD compared to HC. Our study indicates that the levels of free amino acids (FAA) and volatile organic compounds (VOC) differ in AD subjects compared to children with PDD-NOS, who are more similar to HC. Finally, we propose a new perspective on the implications for the interaction between intestinal microbiota and AD.
通过广泛的微生物-哺乳动物共代谢，肠道微生物群已进化到通过肠-脑-微生物群相互作用对健康和疾病产生显著影响。在本附录中，我们总结了我们最近关于未特定的广泛性发育障碍（PDD-NOS）或自闭症（AD）儿童与健康儿童（HC）相比的粪便微生物群和代谢组的研究结果。患有PDD-NOS或AD的儿童粪便微生物群和代谢组（包括神经递质分子）发生了改变。我们假设微生物改变的程度与疾病的严重程度相关，因为与HC相比，PDD-NOS儿童尤其是AD儿童的粪便微生物群和代谢组改变更为明显。我们的研究表明，与PDD-NOS儿童相比，AD受试者的游离氨基酸（FAA）和挥发性有机化合物（VOC）水平有所不同，PDD-NOS儿童与HC更为相似。最后，我们提出了关于肠道微生物群与AD之间相互作用的新观点。
