Nasiri Hadi, Valedkarimi Zahra, Akbari Morteza
Immunology Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Department of Medical Biotechnology, Faculty of Advanced Medical Sciences, Tabriz University of Medical Sciences, Tabriz University of Medical Sciences, Tabriz, Iran.
Mol Cell Biochem. 2025 Jun 12. doi: 10.1007/s11010-025-05325-9.
Significantly affecting mental health, the gut-brain-immune axis shows a complicated interaction between the gastrointestinal tract, immune system, and central nervous system. Maintaining immunological homeostasis and brain function depends on gut bacteria, which are crucial due to their varied microbial populations. Along this axis, communication takes place via immunological responses, microbial metabolites, and brain pathways. Mental health issues like stress, sadness, autism spectrum disorders (ASD), and schizophrenia are linked to dysbiosis and inflammation. Restoring microbial balance and enhancing mental health outcomes show promise from therapeutic approaches, including probiotics, prebiotics, dietary changes, and pharmaceutical and non-pharmacological therapies. Future studies should concentrate on clarifying the gut-brain-immune axis mechanics, creating individualized treatments, and applying results into clinical use. By tackling their underlying causes and encouraging general well-being, this combined approach presents fresh paths for treating mental health problems.
肠道-脑-免疫轴对心理健康有显著影响，它显示了胃肠道、免疫系统和中枢神经系统之间复杂的相互作用。维持免疫稳态和脑功能依赖于肠道细菌，由于其多样的微生物群落，肠道细菌至关重要。沿着这条轴，通过免疫反应、微生物代谢产物和脑通路进行沟通。压力、悲伤、自闭症谱系障碍（ASD）和精神分裂症等心理健康问题与生态失调和炎症有关。恢复微生物平衡并改善心理健康结果在包括益生菌、益生元、饮食改变以及药物和非药物疗法在内的治疗方法中显示出前景。未来的研究应集中于阐明肠道-脑-免疫轴的机制，制定个性化治疗方案，并将研究结果应用于临床。通过解决其根本原因并促进整体健康，这种综合方法为治疗心理健康问题提供了新途径。
